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| Effectiveness of Trastuzumab in Combination with Total Thyroidectomy in the Surgical Treatment of Thyroid Cancer and Influence on Inflammatory Cytokines |
| JIANG Bo-tao, YANG Pei-li, XU An-xia |
| Yunnan Midu County Hospital of Traditional Chinese, Midu Yunnan 675600 |
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Abstract 【Objective】 To explore the effectiveness of trastuzumab in combination with total thyroidectomy in the surgical treatment of thyroid cancer an influence on serum inflammatory cytokines. 【Methods】 A total of 120 patients with thyroid cancer in our hospital were selected and divided into two groups. Patients in the control group received total thyroidectomy, while patients in the observation group received both thyroidectomy and trastuzumab treatment. The clinical effectiveness, hospital stay time after the operation, complications and serum level of inflammatory cytokines (CCL-18 and IL-6) were compared between the two groups. 【Results】 The rate of clinical effectiveness in the observation group was 98.3%(59/60),which was significantly higher than that in the control group [75.0%(45/60)](P<0.05). The average postoperative analgesia and hospital stay, VAS score at 12h and 24h after the operation in the observation group were all significantly lower than those in the control group(P<0.05). The levels of serum CCL-18 and IL-6 were significantly lower in the two groups after the treatment, while the observation group had significantly better results compared to the control group(P<0.05). There was no significant difference in the rate of complications between the two groups(P>0.05). 【Conclusion】 Trastuzumab in combination with total thyroidectomy in the surgical treatment of thyroid cancer has good clinical effect, which can lower serum level of CCL-18 and IL-6, shorten postoperative analgesia and hospital stay, decrease the risk of complications, It should be widely used in clinic.
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Received: 18 January 2019
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2020, Vol. 37 
