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| Clinical Efficacy of Microwave Ablation Combined with Chemotherapy in Treatment of Non-small Cell Lung Cancer Patients with EGFR-TKIs Resistance |
| CHU Xiang-jian, DAI Mei-yun |
| Department of Radiotheray, The People's Hospital of Rugao City, Nantong Jiangsu Province 226500 |
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Abstract 【Objective】To investigate the efficacy of CT-guided percutaneous microwave ablation combined with chemotherapy in the treatment of EGFR-TKIs-resistant non-small cell lung cancer (NSCLC). 【Methods】A total of 89 patients with NSCLC who were admitted to our hospital were recruited in the study. According to different treatment methods after NSCLC became EGFR-TKI drug resistance, patients were divided into two groups: the microwave ablation group (n=48) and the chemotherapy group (n=41). The efficacy and safety of the two groups of patients were compared. Factors associated with progression-free survival (PFS) and overall survival (OS) of NSCLC patients were analyzed. 【Results】The objective response rate of treatment in the microwave ablation group was 93.75% (45/48), which was higher than that in the chemotherapy group [78.05% (32/41)]. The difference was statistically significant (P<0.05). Both groups of patients had different degrees of adverse reactions, and the symptoms were improved after symptomatic treatment. The average PFS of the microwave ablation group was 16.94 months, which was higher than that of the chemotherapy group 14.42 months (P<0.05). The average OS of patients in the microwave ablation group was 20.19 months, which was higher than the average OS of the chemotherapy group 19.66 months, (P<0.05).The results of Cox univariate and multivariate analysis showed that PFS and OS were poor in NSCLC patients with stage Ⅲ-Ⅳ stage, lymph node metastasis and tumor diameter >3 cm. 【Conclusion】For patients with EGFR-TKIs-resistant NSCLC, microwave ablation combined with chemotherapy can effectively control the tumor progress and improve the prognosis of patients.
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Received: 29 August 2019
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2020, Vol. 37 
