|
|
|
| Observation of the Curative Effect of Chinese Medicine Combined with Fimotong in the Treatment of Patients with Premature Ovarian Failure |
| LU Mei-yan, MA Xiao-hong, AN Pei-xing, et al |
| Department of Gynecology, Northwest Women and Children's Hospital Family Planning, Shaanxi Xi'an 710061 |
|
|
|
|
Abstract 【Objective】To study the therapeutic effect of Chinese medicine (Ovarian Zaoshuai Recipe) combined with Fimotong on follicular growth hormone (FSH), serum inhibin B (INHB) and estrogen (E2) in patients with premature ovarian failure. 【Methods】 A total of 102 patients with premature ovarian failure treated in our hospital from August 2015 to August 2018 were divided into two groups according to different treatment methods. The control group was treated with Fimotong, while the observation group was treated with ovariectomy recipe on the basis of Finmotong. The clinical efficacy of the two groups after treatment was analyzed. 【Results】The total effective rate was 92.16% (47/51) in the observation group and 76.47% (39/51) in the control group. The total effective rate in the observation group was higher than that in the control group (P<0.05). There were no significant differences in FSH, INHB and E2 level between the two groups before treatment (P>0.05). However, 3 and 6 months after treatment, serum INHB and E2 levels of the observation group were significantly higher than those of the control group, and the FSH level in the observation was significantly lower than that in the control group. The differences were statistically significant (P<0.05). There was no significant difference in Kupperman score between the two groups before treatment (P>0.05). While the Kupperman score in the observation group was lower than that in the control group at 3 months and 6 months after treatment. The recurrence rate was 9.80% in the observation group and 33.33% (17/51) in the control group. The recurrence rate in the observation group was lower than that in the control group (P<0.05). 【Conclusion】The treatment of premature ovarian failure with Chinese medicine combined with Western medicine can improve the expression of FSH, INHB, and E2, reduce the course of disease, improve the curative effect, and result in a low recurrence rate.
|
|
Received: 23 September 2019
|
|
|
|
|
|
[1] 佟超.线粒体异常与卵巢早衰[J].山东大学学报(医学版),2018,56(4):23-27.
[2] 蔡静,王帅.芬吗通治疗卵巢功能下降及卵巢早衰41例临床观察[J].中外女性健康研究,2017,7(1):169-170.
[3] 胡弘霞.芬吗通改善卵巢储备功能下降及卵巢早衰的效果观察[J].临床合理用药杂志,2018,11(5):56-57.
[4] 徐碧红,李茂清,熊思艺,等.补肾调经膏方对肾虚型卵巢早衰患者性激素水平的影响[J].广州中医药大学学报,2017,34(2):167-172.
[5] 曹泽毅.中华妇产科学[M].第3版.北京:人民卫生出版社,2014:2592-2593.
[6] 王莉,王雅楠.围绝经期和绝经后期妇女的生存质量及其与Kupperman评分的相关性[J].中国老年学杂志,2011,31(15):2941-2943.
[7] Grotto S, Sudriéarnaud B, Drouingarraud V, et al. Dilated cardiomyopathy and premature ovarian failure unveiling propionic aciduria.[J].Clin Chem,2018, 64(4):752-754.
[8] 吴丽婷,石玥,刘雁峰,等.肖承悰治疗卵巢早衰经验[J].中医杂志,2017,58(2):108-110.
[9] 芦艳丽,李娟,韩璐,等.补肾调经膏方治疗肾虚型卵巢早衰的临床研究[J].世界中西医结合杂志,2019,14(3):388-391,395.
[10] 李晓文,张伟涛,许金平,等.仙灵骨葆胶囊联合雌激素替代疗法治疗围绝经期综合征患者的临床疗效[J].医学临床研究,2020,37(8):1216-1219.
[11] 焦雨,许文礼.加减毓麟汤对卵巢早衰患者生殖内分泌相关指标及卵巢功能的影响[J].中国生化药物杂志,2017,37(7):155-156.
[12] Beke A, Piko H, Haltrich I,et al. Study of patterns of inheritance of premature ovarian failure syndrome carrying maternal and paternal premutations[J].BMC Med Genet,2018, 19(1):113.
[13] 赵红艳,倪育淳,白崇智,等.调经助孕胶囊对环磷酰胺化疗大鼠性激素及AMH、INHB的影响[J].中医临床研究,2018,10(20):1-3.
[14] 肖霞,张越华,曹俊凯,等.疏肝健脾解郁汤联合针灸对围绝经期抑郁症患者更年期kupperman评分和焦虑抑郁评分的影响[J].陕西中医,2018,39(11):1617-1619. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(9): 1399-1401. |
|
|
|
|
2020, Vol. 37 
