内镜下球囊扩张联合糖皮质激素治疗食管癌放疗后狭窄的疗效

doi:10.3969/j.issn.1671-7171.2020.12.008

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Abstract 【Objective】To investigate the effect of balloon dilatation combined with hormone in the treatment of esophageal cancer after radiotherapy. 【Methods】A total of 68 patients with esophageal cancer stenosis after radiotherapy were randomly divided into two groups, 34 cases in each group. The control group was treated with endoscopic balloon dilatation, while the observation group was treated with glucocorticoid. The curative effect, complications and dysphagia before and after treatment were compared between the two groups. Albumin (ALB), transferrin (TF), hemoglobin (Hb), lymphocyte count (TCL), body weight, nutritional status and immune function were compared between the two groups. 【Results】After intervention, the stenosis in the observation group was improved, and the total effective rate was 100%, which had no significant difference compared with 94.12% of the control group (P>0.05). The cure rate of the observation group was 79.41%, which was significantly higher than 55.88% of the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). At the time of reexamination, the proportion of grade 0, grade 1-2 in the two groups was significantly higher than that before treatment (P<0.05). The proportion of grade 0 in the observation group was significantly higher than that in the control group (P<0.05). The levels of ALB, TF, Hb and TCL in the two groups after intervention were higher than those before treatment, and the levels of ALB, TF and TCL in the observation group were significantly higher than those in the control group (P<0.05). The levels of CD4⁺, CD4⁺/CD8⁺ in the two groups were higher than those before treatment, and CD8⁺ was lower than that before treatment (P<0.05), and the levels of CD4⁺, CD4⁺/CD8⁺ and CD8⁺ in the observation group were higher than those in the control group (P<0.05). 【Conclusion】Endoscopic balloon dilatation combined with glucocorticoid in the treatment of esophageal cancer patients with stenosis after radiotherapy can improve the cure rate of stenosis, promote the further improvement of swallowing function, nutritional status and immune function.

Key words： Esophageal Stenosis/SU Esophageal Stenosis/DT Esophageal Neoplasms/CO Endoscopy

Received: 11 August 2020

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R735.1

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	ZHU Chao-mang
	ZHANG Qun
	YIN Hong-mei
	et al

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ZHU Chao-mang,ZHANG Qun,YIN Hong-mei, et al. Efficacy of Endoscopic Balloon Dilatation Combined with Glucocorticoid in the Treatment of Esophageal Cancer Stenosis after Radiotherapy[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(12): 1789-1792.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.12.008 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I12/1789

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