慢性阻塞性肺疾病患者下呼吸道感染对β-catenin相对表达量的影响

doi:10.3969/j.issn.1671-7171.2020.01.025

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Abstract 【Objective】To investigate the effect of lower respiratory tract infection on the relative expression of beta-catenin in patients with chronic obstructive pulmonary disease (COPD).【Methods】A total of 94 patients with chronic obstructive pulmonary disease diagnosed and treated in the Department of Respiratory Medicine of the People's Hospital of Wuhan University were selected and divided into COPDⅠ(n=29) group, COPDⅡ(n=35) group, and COPDⅢ(n=30) group according to the pulmonary function classification of patients. According to whether the patients had lower respiratory tract infection, they were further divided into the infected group (n=56) and uninfected (n=38) group. The influence of lung function and respiratory tract infection on the relative expression of β-catenin was detected and analyzed. The relative expression of β-catenin in predicting the value of lower respiratory tract infection in patients with COPD was analyzed by ROC curve. 【Results】The FVC (forced vital capacity), FEV1 (forced expiratory volume in the first second), FEV1/FVC and β-catenin expression were statistically significant in the lung function of the patients with different COPD condition (P<0.05). With the aggravation of the COPD patients, the FVC, FEV1, FEV1/FVC decreased significantly (P<0.05), and the relative expression of β-catenin increased significantly (P<0.05). The FVC, FEV1 and FEV1/FVC in the infected group were significantly lower than those in the uninfected group (P<0.05), while the relative expression of β-catenin in the infected group was significantly higher than that in the uninfected group (P<0.05). The relative expression of β-catenin was negatively correlated with FVC, FEV1 and FEV1/FVC (P<0.05). The ROC curve was used to analyze the predictive value of the relative expression of beta -catenin in respiratory tract infection in patients with chronic obstructive pulmonary disease (COPD). The area under the ROC curve of the relative expression of β-catenin for the diagnosis of lower respiratory tract infection in COPD patients was 0.875.【Conclusion】There is a significant correlation between the abnormal expression of Wnt/beta-catenin signaling pathway and pulmonary function in COPD patients. The change of relative expression of beta-catenin in COPD patients caused by lower respiratory tract infection suggest it has a certain diagnostic value for COPD patients.

Key words： Pulmonary Disease,Chronic Obstructive Respiratory Tract Infections

Received: 21 December 2018

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R563

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	BAO Zhi-wei
	ZENG Shao-lin

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BAO Zhi-wei,ZENG Shao-lin. Effect of Lower Respiratory Tract Infection on β-catenin Signaling Pathway in Patients with Chronic Obstructive Pulmonary Disease[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(1): 79-82.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.01.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I1/79

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