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| Changes and Significance of Serum TGF-β1 in Children with Hypoxic Ischemic Encephalopathy |
| HUANG Jian, WU Ji-wei, LUO Rui-bin,et al |
| Department of Neonatology, Longgang Central Hospital, Shenzhen 518116, China |
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Abstract 【Objective】To investigate the clinical significance of dynamic monitoring of serum TGF-β1 in children with hypoxic ischemic encephalopathy (HIE). 【Methods】A total of 40 children with HIE admitted to the neonatology department of our hospital from January 2017 to December 30, 2018 were enrolled. According to the HIE clinical classification criteria, they were divided into mild group (19 cases), moderate group (19 cases) and severe group (10 cases). Twenty healthy newborns of hospital delivery during the same period were included in the control group. Levels of peripheral blood transforming growth factor-β1 (TGF-β1) were measured and neonatal neurobehavioral assay (NBNA) were examined in all groups. The diagnostic value of TGF-β1 for moderate to severe HIE was analyzed using ROC curves. 【Results】There were no significant differences in gender, gestational age, mode of delivery, maternal primipara, abortion history, intrauterine infection and premature rupture of membranes in the four groups (P>0.05). There were significant differences in TGF-β1 levels between 24 h and 72 h after birth (P<0.05). However, one week after birth, there was no significant difference in TGF-β1 levels in all groups (P>0.05). The decrease of TGF-β1 level and NBNA score of the HIE children reflected the severity of HIE; the difference was statistically significant (P<0.05). At 24 h, 72 h, and 1 week after birth, TGF-β1 levels were positively correlated with NBNA scores (r=0.523, 0.513, 0.428). At 24 h after birth, the optimal critical point for TGF-β1 diagnosis of moderate-severe HIE was 15.6 μg/L, the sensitivity was 71.5%, the specificity was 79.5%, and the area under the AUC curve was 0.78. 【Conclusion】In the order of mild-moderate-severe HIE, TGF-β1 levels decrease and are positively correlated with NBNA scores.
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Received: 20 May 2019
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2019, Vol. 36 
