Effect of Dexmedetomidine Anesthesia on Postoperative Cognitive Function and Hemodynamic Parameters in Elderly Patients undergoing Radical Resection of Colorectal Cancer
JIANG Rong-juan, SUN Yan, LIU Shao-xing,et al
Chengdu second people's Hospital ,SichuanChengdu,610016
Abstract【Objective】To investigate the effect of dexmedetomidine(Dex) anesthesia on postoperative cognitive function and hemodynamic parameters in elderly patients undergoing radical resection of colorectal cancer. 【Methods】A total of 108 elderly patients with colorectal cancer were divided into two groups, the observation group (n=55) and the control group (n=53). Dex was infused at a rate of 0.6μg/(kg?h) until 30 min before the end of surgery after a loading dose of Dex 1.0 μg/kg was infused at 15 min after anesthesia induction in the observation group, while the control group received equal volume of normal saline. The stress response and hemodynamic changes of the two groups were compared before, after, during and after extubation . The incidence of cognitive function and cognitive impairment (POCD) were compared between groups before anesthesia as well as 6h, 12h, 24h and 72h after anesthesia. 【Results】After anesthesia, the stress level of the observation group was lower than that before anesthesia (P<0.05). The index of the two groups was significantly different (P<0.05).The heart rate, blood pressure, and left ventricular ejection fraction index of the observation group were significantly decreased after anesthesia. The hemodynamic index of the observation group was significantly better than that of the control group (P<0.05). The cognitive function MMSE scores of the observation group was significantly better than those of the control group at 6h, 12h, and 24h after anesthesia (P<0.05). There was no significant difference in the MMSE scores between the two groups at the 72h after anesthesia (P>0.05); The incidence of COPD in the observation group was significantly lower than that in the control group at 6h and 12h after anesthesia (P<0.05). 【Conclusion】The Dex anesthesia is beneficial to stabilize the stress response and hemodynamic changes during anesthesia induction period in elderly patients undergoing rectal cancer resection. It also promotes postoperative cognitive function recovery, which is worthy of clinical promotion.
2019, Vol. 36 
