AbstractObjective To investigate the effect of lung volume reduction surgery (LVRS) on pulmonary function and vascular endothelial function in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty-two patients with COPD admitted to our hospital from February 2013 to June 2017 were divided into observation group and control group according to their surgical tolerance , with 31 in each group. LVRS was performed in the observation group after the diagnosis of end-stage COPD, and LVRS was performed in the control group 3 months after the diagnosis of end-stage COPD. Blood pressure, pulmonary function and endothelium dependent diastolic function (FMD) were compared between the two groups on the day of COPD diagnosis and at two time points of 3 months follow-up.Results After 3 months of follow-up diagnosis, the blood pressure and lung residual volume/lung capacity ratio of the control group increased significantly and FMD decreased. The blood pressure value, FEV1 predictive value, FVC predictive value, lung residual gas volume/lung capacity ratio of the observation group were all improved compared with those before LVRS,the improvement was significant (P<0.05), and the improvement of lung function index in the observation group was higher than that in the control group (P<0.05). The observation group underwent LVRS. For every 1% increase in FEV1 or FVC, FMD increased by 0.13% and 0.11%, respectively (P<0.05). Conclusion LVRS in patients with COPD can improve lung function and further improve vascular endothelial function.
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(5): 985-987.
2019, Vol. 36 
