肺减容术对慢性阻塞性肺气肿患者肺功能和血管内皮依赖性舒张功能的影响

doi:10.3969/j.issn.1671-7171.2019.02.010

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Abstract Objective To investigate the effect of lung volume reduction surgery (LVRS) on pulmonary function and vascular endothelial function in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty-two patients with COPD admitted to our hospital from February 2013 to June 2017 were divided into observation group and control group according to their surgical tolerance , with 31 in each group. LVRS was performed in the observation group after the diagnosis of end-stage COPD, and LVRS was performed in the control group 3 months after the diagnosis of end-stage COPD. Blood pressure, pulmonary function and endothelium dependent diastolic function (FMD) were compared between the two groups on the day of COPD diagnosis and at two time points of 3 months follow-up.Results After 3 months of follow-up diagnosis, the blood pressure and lung residual volume/lung capacity ratio of the control group increased significantly and FMD decreased. The blood pressure value, FEV1 predictive value, FVC predictive value, lung residual gas volume/lung capacity ratio of the observation group were all improved compared with those before LVRS,the improvement was significant (P<0.05), and the improvement of lung function index in the observation group was higher than that in the control group (P<0.05). The observation group underwent LVRS. For every 1% increase in FEV1 or FVC, FMD increased by 0.13% and 0.11%, respectively (P<0.05). Conclusion LVRS in patients with COPD can improve lung function and further improve vascular endothelial function.

Key words： Pulmonary Disease Chronic Obstructive/SU Pneumonectomy

Received: 29 January 2018

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2019.02.010 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2019/V36/I2/246

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