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| Value of Monoclonal Bands Detected by Serum Protein Electrophoresis for Multiple Myeloma Diagnosis |
| YAN Xiang-hong, WANG Lin, NI Juan, et al |
| Changsha Center Hospital, Changsha, Hunan, 410004, China |
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Abstract 【Objective】To investigate the clinical value of monoclonal bands detected by serum protein electrophoresis for multiple myeloma(MM)diagnosis. 【Methods】A total of 103 patients with MM in our hospital were selected as the experimental group and 100 healthy volunteers of physical examination as the control group. Detection of monoclonal bands by serum protein electrophoresis was compared between the two groups. 【Results】The M protein secreted by MM patients was mainly IgG type, followed by IgA type. The albumin level of patients with multiple myeloma was [31.40 (25.80~35.80)] g/L, which was lower than that of the control group [46.00 (44.00~47.00)] g/L. The globulin expression level was [45.44 (30.70~54.30)] g/L, which was higher than that of the control group [26.67 (25.00~29.00)] g/L. The differences of the two protein detection results between the two groups were statistically significant (P＜0.05).The immunoglobulin content of patients with MM is positively correlated with M protein type. In IgG type, 89.58% (43/48) of M protein bands appeared in the γ region. In IgA type, 53.57% (15/28) of M protein bands appeared in the β region. In IgM type, all of M protein bands appeared in the γ zone. The detection rate of the light chain of M protein bands were low. The positive rate of serum protein electrophoresis for M protein bands was 82.52% (85/103),which was higher than that of immunoglobulin quantitative detection for M protein 71.84% (74/103). There was a statistically significant difference in the detection rate of M protein between the two methods (χ2=29.607,P<0.05). 【Conclusion】Detection of M protein bands by serum protein electrophoresis can effectively improve the detection rate of multiple myeloma. Thus it can avoid the burden of diagnosis and treatment caused by ineffective bone marrow puncture.
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Received: 20 August 2019
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2019, Vol. 36 
