心脏彩超联合D-二聚体对慢性阻塞性肺疾病患者发生急性肺栓塞的预测价值

doi:10.3969/j.issn.1671-7171.2026.09.022

Abstract
Figure/Table
References
Related Citation (3)

Download: PDF (1187 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To explore the predictive value of echocardiography combined with D-dimer for acute pulmonary embolism in patients with chronic obstructive pulmonary disease (COPD).【Methods】A total of 112 patients with COPD admitted to Luoyang Central Hospital from January 2021 to January 2024 were selected and divided into an observation group (those who developed acute pulmonary embolism, n=29) and a control group (those who did not develop acute pulmonary embolism, n=83) according to whether acute pulmonary embolism occurred. All patients underwent echocardiography after admission. The pulmonary artery diameter, right ventricular diameter, right atrial diameter, right ventricular performance index, and D-dimer level were compared between the two groups. Multivariate logistic regression analysis was used to analyze the risk factors for acute pulmonary embolism in patients with COPD, and the receiver operating characteristic (ROC) curve was used to evaluate the efficacy of echocardiography combined with D-dimer in predicting acute pulmonary embolism in patients with COPD.【Results】The pulmonary artery diameter, right ventricular diameter, and right atrial diameter of the patients in the observation group were all greater than those in the control group, and the right ventricular performance index and D-dimer level were higher than those in the control group, with statistically significant differences (all P<0.05). Multivariate logistic regression analysis showed that a larger pulmonary artery diameter, right ventricular diameter, and right atrial diameter, as well as a higher right ventricular performance index and D-dimer level, were all risk factors for acute pulmonary embolism in patients with COPD (all P<0.05), and the area under the curve of echocardiography combined with serum D-dimer level detection for predicting acute pulmonary embolism in patients with COPD was 0.975.【Conclusion】Echocardiography combined with serum D-dimer level detection has high efficacy in predicting acute pulmonary embolism in patients with COPD, and can provide a reference for the diagnosis and treatment of patients with COPD.

Key words： Chronic Obstructive Pulmonary Disease Acute Pulmonary Embolism Echocardiography D-Dimer

Received: 10 June 2025

PACS:

R563.9

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Hang
	ZHAO Bing
	GAO Yafei

Cite this article:

ZHANG Hang,ZHAO Bing,GAO Yafei. Predictive Value of Echocardiography Combined with D-Dimer for Acute Pulmonary Embolism in Patients with Chronic Obstructive Pulmonary Disease[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(9): 1489-1492.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.09.022 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I9/1489

[1] 梁振宇,王凤燕,陈子正,等. 2023年GOLD慢性阻塞性肺疾病诊断、管理及预防全球策略更新要点解读[J].中国全科医学,2023,26(11):1287-1298.
[2] Kagima J, Stolbrink M, Masheti S,et al. Diagnostic accuracy of combined thoracic and cardiac sonography for the diagnosis of pulmonary embolism: a systematic review and meta-analysis[J]. PLoS One, 2020, 15(9):e0235940.
[3] 武艳娇,申海龙,翟江,等. 心脏彩超对AECOPD并发肺栓塞的评估价值[J]. 影像科学与光化学,2022,40(1):109-113.
[4] Biciusca T, Gruenewald L D, Martin S S,et al. Optimizing resource allocation: cost-effectiveness of specified D-dimer cut-offs in cancer patients with suspected venous thromboembolism[J]. J Thromb Thrombolysis, 2024, 57(6):996-1007.
[5] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013年修订版)[J]. 中国医学前沿杂志(电子版),2014,6(2):67-79.
[6] 杨光田. 肺血栓栓塞症的诊断与治疗进展[C].中华医学会急诊医学分会第十五次全国急诊医学学术年会论文集. 2012:54-57.
[7] 卢祥婷,李娅,王忠平,等. 云南省高海拔地区急性肺栓塞患者的临床特征分析[J]. 中华心血管病杂志,2022,50(1):36-42.
[8] Duus L S, Vesterlev D, Nielsen A B,et al. COPD: pulmonary vascular volume associated with cardiac structure and function[J]. Int J Cardiovasc Imaging, 2024, 40(3):579-589.
[9] 刘莉,张伟,赵芳. 心脏彩超联合MSCT、D-二聚体在诊断急性肺栓塞中的应用[J]. 中国CT和MRI杂志,2020,18(11):91-93.
[10] 段新,沈文茜,王爽,等. 三尖瓣环收缩期位移与三尖瓣反流峰值压差比值对急性肺栓塞患者右心室-肺动脉偶联的评估[J]. 中华超声影像学杂志,2021,30(11):982-987.
[11] Lyhne M D, Hansen J V, Dragsbk S J,et al. Oxygen therapy lowers right ventricular afterload in experimental acute pulmonary embolism[J]. Crit Care Med, 2021, 49(9):e891-e901.
[12] Pullamsetti S S, Tello K, Seeger W. Utilising biomarkers to predict right heart maladaptive phenotype: a step toward precision medicine[J]. Eur Respir J, 2021, 57(4):2004506.
[13] Voelker R. Cardiac ultrasound uses artificial intelligence to produce images[J]. JAMA, 2020, 323(11):1034.
[14] 李玉环,王希,李彤彤. 血浆D-二聚体、纤维蛋白原在老年社区获得性肺炎合并肺栓塞中的临床诊断价值[J]. 中国老年学杂志,2023,43(5):1083-1085.