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| Predictive Value of D-Dimer-to-Fibrinogen Ratio for Progressive Cerebral Infarction |
| GUO Yanli, LIU Shuang, LEI Pei |
| Department of Medical Laboratory, Fangcheng County People's Hospital, Nanyang Henan 473200 |
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Abstract 【Objective】 To investigate the predictive value of the D-dimer-to-fibrinogen ratio (DFR) at admission for progressive cerebral infarction. 【Methods】 A total of 92 patients with acute cerebral infarction admitted to our hospital from February 2022 to May 2025 were enrolled. The levels of D-dimer and fibrinogen were measured at admission, and the DFR was calculated. The National Institutes of Health Stroke Scale (NIHSS) scores were assessed at admission and 72 h after admission. Progressive cerebral infarction was defined as an increase of ≥4 points in the NIHSS score within 72 h (the progression group). The differences in DFR between the progression group and non-progression group were compared. Multivariate Logistic regression analysis was performed to evaluate the correlation between DFR and progressive cerebral infarction. Receiver operating characteristic (ROC) curves were plotted to assess the predictive performance of DFR. 【Results】 Among the 92 patients, 22 developed progressive cerebral infarction, accounting for 23.91%. The DFR in the progression group was significantly higher than that in the non-progression group (P<0.05). Multivariate logistic regression analysis showed that, after adjustment for confounding factors including age, baseline NIHSS score, history of atrial fibrillation, and intravenous thrombolysis, DFR ≥0.27 remained an independent predictor of progressive cerebral infarction (OR=4.908, P<0.05). ROC curve analysis showed that the AUC of DFR for predicting progressive cerebral infarction within 72 h was 0.859 and the optimal cutoff value was 0.27, with a sensitivity of 77.3% and a specificity of 78.6%. 【Conclusion】 An elevated DFR at admission is associated with an increased risk of progressive cerebral infarction within 72 h. DFR has certain predictive value for progressive cerebral infarction and may serve as an auxiliary indicator for early risk stratification in patients with acute cerebral infarction.
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Received: 04 January 2026
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2026, Vol. 43 
