罗哌卡因联合舒芬太尼患者自控硬膜外镇痛对无痛分娩产妇产程和发热情况的影响

doi:10.3969/j.issn.1671-7171.2026.09.012

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Abstract 【Objective】To investigate the effects of patient-controlled epidural analgesia (PCEA) using ropivacaine combined with sufentanil on labor progress and fever in women undergoing labor analgesia. 【Methods】 A total of 96 women who underwent labor analgesia at Minquan County Hospital of Traditional Chinese Medicine from January 2020 to December 2023 were randomly divided into a control group and an observation group, with 48 cases in each group. Both groups received PCEA. The control group received ropivacaine alone, whereas the observation group received ropivacaine combined with sufentanil. The analgesic effects, duration of labor, mode of delivery, and neonatal Apgar scores after delivery were compared between the two groups. Oxidative stress indicators [endothelin, cortisol, and superoxide dismutase (SOD)] and inflammatory factors [interleukin-6 (IL-6), interleukin-10(IL-10), and tumor necrosis factor α (TNF-α)] were measured before analgesia and 1 h after delivery. Visual analog scale (VAS) scores and body temperature were assessed before analgesia, 1 h after analgesia, immediately after delivery, and 1 h after delivery. 【Results】Compared with the control group, the observation group had a shorter onset time of anesthesia, fewer patient-controlled analgesia administrations, and a lower dose of local anesthetic, but a longer duration of anesthesia maintenance (all P<0.05). VAS scores at 1 h after analgesia, immediately after delivery, and 1 h after delivery were lower in the observation group than in the control group (all P<0.05). The rate of vaginal delivery was higher in the observation group than in the control group, and neonatal Apgar scores at 1 and 5 min after delivery were also higher (all P<0.05). 1 h after delivery, the levels of oxidative stress indicators and inflammatory factors in both groups were higher than those before analgesia (all P<0.05); however, the levels of these markers in the observation group were lower than those in the control group (all P<0.05). Body temperatures immediately after delivery and 1 h after delivery in the observation group were lower than those in the control group (all P<0.05). 【Conclusion】PCEA with ropivacaine combined with sufentanil can effectively improve analgesic efficacy, shorten the duration of labor, alleviate postpartum oxidative stress and inflammation, and reduce the risk of elevated maternal body temperature. It is worthy of clinical application.

Key words： Labor Analgesia Ropivacaine Sufentanil Epidural Anesthesia Labor Stage Fever

Received: 25 November 2025

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R714.3

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	ZHANG Yanxia

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ZHANG Yanxia. Effects of Patient-Controlled Epidural Analgesia Using Ropivacaine Combined with Sufentanil on Labor Progress and Fever in Women Undergoing Labor Analgesia[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(9): 1451-1454.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.09.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I9/1451

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