颅脑MRI联合经颅黑质超声检查对帕金森病与血管性帕金森综合征的鉴别诊断价值

doi:10.3969/j.issn.1671-7171.2025.12.005

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Abstract 【Objective】 To investigate the diagnostic value of cranial magnetic resonance imaging (MRI) combined with transcranial sonography (TCS) of the substantia nigra in differentiating Parkinson's disease (PD) from vascular parkinsonism (VPS).【Methods】 Thirty-eight PD patients (the PD group), 30 VPS patients (the VPS group), and 37 healthy volunteers (the control group) were enrolled. Cranial MRI and TCS findings were compared among the three groups. Receiver operating characteristic (ROC) curves were used to analyze the diagnostic value of MRI and TCS for PD and VPS.【Results】 The width of the pars compacta of the substantia nigra (WPCSN) and the WPCSN/midbrain diameter ratio were significantly lower in both the PD and VPS groups compared to the control group, with the PD group showing lower values than the VPS group (all P<0.05). The bilateral hyperechogenic areas of the substantia nigra, the total hyperechogenic area, and the ratio of hyperechogenic area to total midbrain area (S/M) in the PD and VPS groups were significantly higher than those in the control group, and they were higher in the PD group than in the VPS group (all P<0.05). Among the individual MRI and TCS parameters, the bilateral S/M showed the highest diagnostic value for differentiating PD from VPS. Combined MRI and TCS assessment demonstrated higher diagnostic performance than any single MRI or TCS parameter.【Conclusion】 The combined application of both cranial MRI and TCS can significantly improve the diagnostic efficiency in distinguishing PD from VPS, providing a valuable and noninvasive imaging basis for accurate clinical differentiation.

Key words： Parkinson Disease Parkinsonian Disorders Magnetic Resonance Imaging Ultrasonography Diagnosis, Differential

Received: 01 July 2025

PACS:

R742.5

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.12.005 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I12/2032

[1] HOPFNER F, HÖGLINGER G, TRENKWALDER C. Definition and diagnosis of Parkinson's disease: guideline "Parkinson's disease" of the German Society of Neurology[J].J Neurol,2024, 271(11): 7102-7119.
[2] 陈苗,张岗,王文佳,等. 合成MRI联合VBM脑分区在早期帕金森病诊断中的应用[J].磁共振成像,2023,14(10):20-25.
[3] 庞坚信,张黄琦,鲍统安,等. 基于人工智能MRI脑区容积比变化对早期帕金森病的诊断价值[J].浙江医学,2024,46(13):1381-1386.
[4] 中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍专业委员会. 中国帕金森病的诊断标准(2016版)[J].中华神经科杂志,2016,49(4):268-271.
[5] 中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍专业委员会. 中国血管性帕金森综合征诊断与治疗专家共识[J].全科医学临床与教育,2017,15(4):364-367.
[6] 王宗英,于文文,吴晓丽,等. 多模态MRI对帕金森病及多系统萎缩鉴别诊断价值研究[J].实用放射学杂志,2023,39(9):1396-1400.
[7] 谢晴晴,胡春峰. 经颅黑质超声检查及MRI在帕金森病诊断评估中的价值分析[J].医学影像学杂志,2024,34(8):16-19.
[8] 徐晓君,阮伟伟,刘芳,等. 多模态多探针PET/MRI鉴别诊断帕金森病与进行性核上性麻痹[J].中国医学影像技术,2023,39(10):1455-1460.
[9] 李明龙,李祥林,刘苗苗,等. 定量磁共振成像技术在帕金森病诊断中的研究进展[J].磁共振成像,2025,16(4):108-113.
[10] 余前娥,崔佳琪,张体江. 多模态MRI及影像遗传学在帕金森病中的研究进展[J].磁共振成像,2025,16(2):124-129.
[11] MULROY E, ERRO R, BHATIA K P, et al. Refining the clinical diagnosis of Parkinson's disease[J].Parkinsonism Relat Disord,2024, 122: 106041.
[12] 杨媛,高平. 帕金森病伴快速眼动睡眠行为障碍的静息态功能磁共振研究进展[J].中国医疗设备,2025,40(4):158-163.
[13] 黎庆,盛金平,蒋锐,等. 血管性帕金森综合征患者的MRI特征及诊断价值[J].中国实用神经疾病杂志,2023,26(1):25.