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| Clinical Significance of Serum Cytokine Level Measurement in Children Infected with Influenza A and B Viruses |
| HUANG Liang, SHI Yi |
| Department of Laboratory Medicine, Punan Hospital, Pudong New Area, Shanghai 200125 |
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Abstract 【Objective】 To explore the clinical significance of measuring serum cytokine levels in children infected with influenza A and B viruses. 【Methods】 A total of 102 children infected with influenza A and B viruses were included in this study. Among them, 38 were infected with the H1N1 strain (Group A), 34 with the H3N2 strain (Group B), and 30 with influenza B (Group C). Another 40 healthy children were selected as the control group. Based on the severity of their condition, the patients were divided into a mild group (78 cases) and a severe group (24 cases). Serum levels of interferon-γ(IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin-17 (IL-17), IL-10, IL-8, IL-6, IL-4, and IL-2 were compared among the groups. 【Results】 Compared to the healthy control group, serum levels of IL-6, IL-8, IL-17, TNF-α, and IFN-γ were significantly elevated in both mild and severe groups (P<0.05), with the severe group showing higher levels than the mild group (P<0.05). There were no statistically significant differences in IL-4 and IL-10 levels among the three groups (P>0.05). IL-2 levels in the severe group were significantly lower than those in the mild group and the control group (P<0.05), and the mild group had lower IL-2 level than the control group (P<0.05). Serum levels of IL-6 and TNF-α in Groups B and C were higher than in Group A (P<0.05), but there was no significant difference between Groups B and C (P>0.05). No statistically significant differences were observed in the levels of other indicators among the three groups (P>0.05). 【Conclusion】 After infection with influenza A and B viruses, children exhibited significantly elevated levels of IL-6, IL-8, IL-17, TNF-α, and IFN-γ, especially in severe cases. Measurement of cytokine levels can serve as an important indicator for assessing the severity and prognosis of influenza in children.
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Received: 09 May 2024
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2025, Vol. 42 
