纤维蛋白原及D-二聚体水平与脑梗死患者认知功能障碍的相关性

doi:10.3969/j.issn.1671-7171.2024.07.028

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Abstract 【Objective】 To investigate the relationship between serum fibrinogen (FIB) and D-dimer (D-D) levels and cognitive dysfunction in patients with cerebral infarction.【Methods】 Eighty-two patients with cerebral infarction were divided into mild, moderate, and severe groups according to the degree of cognitive dysfunction. Additionally, 30 healthy individuals undergoing physical examination during the same period were selected as the control group. Serum FDP and D-D levels were compared among all groups, and cognitive function was assessed as well. Pearson analysis was used to evaluate the correlation between FIB and D-D levels and the degree of cognitive dysfunction. Spearman analysis was performed to determine the correlation of MoCA scores with FIB and D-D levels.【Results】 Compared to the control group, FIB and D-D levels were significantly higher in the mild, moderate, and severe groups (P<0.05). FIB and D-D levels in the severe group were higher than those in the mild and moderate groups (P<0.05). Levels of FIB and D-D were positively correlated with the degree of cognitive dysfunction in patients with cerebral infarction (both P<0.05). There was a linear relationship between FIB and D-D levels and cognitive function (R²=0.531 and 0.478, respectively).【Conclusion】 The degree of cognitive dysfunction in patients with cerebral infarction is positively correlated with both serum FIB and D-D levels, which can be served as independent predictors of the severity of cognitive dysfunction in these patients.

Key words： Brain Infarction Fibrinogen/BL Fibrin Fibrinogen Degradation Products/BL Cognitive Dysfunction

Received: 26 December 2023

PACS:

R743.33

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	Articles by authors
	ZHANG Jianqun
	LI Xinqiang
	WANG Shuanwei

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ZHANG Jianqun,LI Xinqiang,WANG Shuanwei. Relationship of Fibrinogen and D-Dimer Levels with Cognitive Dysfunction in Patients with Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(7): 1058-1060.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.07.028 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I7/1058

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