肝脏硬度值及血清CER、AST水平在ALT轻度升高乙肝患者肝纤维化中的评估价值

doi:10.3969/j.issn.1671-7171.2024.05.007

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Abstract 【Objective】To explore the value of ultrasound in detecting liver stiffness (LSM), serum ceruloplasmin (CER) and aspartate aminotransaminase (AST) in evaluating liver fibrosis of patients with mild elevation of alanine aminotransferase (ALT).【Methods】From June 2020 to June 2022, 100 patients with hepatitis B showing slightly elevated ATL admitted to our hospital were divided into non-fibrosis group (n=10) and fibrosis group (n=90) according to the stage of liver fibrosis. According to the severity of liver fibrosis, patients were divided into severe fibrosis group (n=42), moderate fibrosis group (n=36), and mild fibrosis group (n=12). The value of ALT, albumin (ALB), AST and CER, LSM was compared in different groups of patients. The ROC curve of subjects was drawn to analyze the evaluation value of CER, AST, LSM on liver fibrosis in hepatitis B patients with mild elevation of ALT.【Results】There was no statistically significant difference in ALT and ALB between the two groups of fibrosis and non-fibrosis patients (P>0.05); The AST and LSM of the fibrosis group were higher than those of the non-fibrosis group, and the CER of the fibrosis group was lower than that of the non-fibrosis group, with statistical significance (P<0.05). ROC curve analysis showed that the area under the curve of AST, CER and LSM for evaluating liver fibrosis in hepatitis B patients with slightly elevated ATL was 0.914, 0.616 and 0.946, respectively (P<0.05). The CER of the severe fibrosis group, the moderate fibrosis group, and the mild fibrosis group gradually increased, and the difference was statistically significant (P<0.05); The AST and LSM gradually decreased in the severe fibrosis group, moderate fibrosis group, and mild fibrosis group, and the difference was statistically significant (P<0.05).【Conclusion】There are differences in AST, CER and LSM in patients with hepatitis B with slightly elevated ATL at different levels of fibrosis. AST, CER and LSM have certain evaluation value for liver fibrosis and can be used for early diagnosis or evaluation of liver fibrosis in such patients.

Key words： Hepatic Fibrosis Hepatitis B Ceruloplasmin Aspartate Aminotransferases Alanine Transaminase

Received: 21 January 2022

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R575.2

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DU Xiangshan. Application of Liver Stiffness, Serum CER and AST Levels in Evaluating Liver Fibrosis of Patients with ALT Elevated Hepatitis B[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(5): 666-668.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.05.007 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I5/666

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