布地奈德福莫特罗联合吡非尼酮胶囊治疗COPD合并肺间质纤维化的临床疗效及构建并验证列线图模型<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2024.05.006

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Abstract 【Objective】To explore the efficacy of budesonide-formoterol combined with pirfenidone capsules in treating Chronic Obstructive Pulmonary Disease (COPD) with pulmonary interstitial fibrosis, and at constructing and validating a nomogram model for predicting clinical efficacy.【Methods】From September 2019 to December 2023, 107 patients with COPD combined with pulmonary interstitial fibrosis, who were treated with budesonide-formoterol combined with pirfenidone capsules in the Department of Respiratory and Critical Care Medicine at the First Affiliated Hospital of Henan University, were selected. Based on treatment outcomes, they were divided into an improvement group (markedly effective+effective) and an ineffective group (ineffective). Clinical data and laboratory results of both groups were analyzed through univariate analysis, and factors of statistical significance were subjected to multivariate regression analysis to construct a nomogram for identifying factors influencing treatment outcomes.【Results】Out of the 107 patients included, 83 were in the improvement group (77.57%) and 24 in the ineffective group (22.43%). There were no statistically significant differences between the two groups in terms of age, gender, BMI, history of alcohol abuse, diabetes, hypertension, heart rate, white blood cell count, PaO₂, PaCO₂, lactate, and CRP (P>0.05). Significant differences were found between the improvement and ineffective groups regarding smoking history, pulmonary function classification, COPD duration, APACHEⅡscore, and NT-proBNP (P<0.05). Multivariate regression analysis revealed that a history of smoking, pulmonary function classification of Ⅲ-Ⅳ,long duration of COPD, high APACHEⅡ score, and high NT-proBNP were independent risk factors for ineffective treatment in patients with COPD combined with pulmonary interstitial fibrosis (P<0.05). A nomogram was constructed, demonstrating good predictive performance.【Conclusion】The risk factors affecting the efficacy of budesonide-formoterol combined with pirfenidone capsules in treating patients with COPD combined with pulmonary interstitial fibrosis were identified as a history of smoking, pulmonary function classification of Ⅲ-Ⅳ, long duration of COPD, high APACHEⅡ score, and high NT-proBNP. These can serve as predictive tools for the efficacy in patients with COPD combined with pulmonary interstitial fibrosis, providing a reference for clinical treatment decision-making.

Key words： Pulmonary Disease, Chronic Obstructive Pulmonary Fibrosis Budesonide, Formoterol Fumarate Drug Combination Pyridones

Received: 15 March 2024

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	SHANG Yan

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SHANG Yan. Construction and Validation of a Nomogram Model for the Clinical Efficacy of Budesonide-Formoterol Combined with Pirfenidone Capsules in the Treatment of COPD with Pulmonary Interstitial Fibrosis[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(5): 661-665.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.05.006 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I5/661

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