Vitapex糊剂根管填充治疗儿童乳牙牙髓炎的疗效及对IL-1β、IL-18水平的影响

doi:10.3969/j.issn.1671-7171.2024.04.007

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Abstract 【Objective】To explore the therapeutic effect of Vitapex paste root canal filling on pulpitis of primary teeth in children and its impact on the levels of interleukin-1β (IL-1β) and interleukin-18 (IL-18). 【Methods】A total of 92 children with primary pulpitis treated at the Third Hospital of Xi'an City from March 2020 to March 2022 were selected and randomly divided into an observation group (n=46, 52 affected teeth) and a control group (n=46, 56 affected teeth) using a random number table method. The observation group received root canal filling with Vitapex paste, while the control group received treatment with zinc oxide clove oil paste. We compared the swelling disappearance time, pain relief time, degree of tooth pain, success rate of root canal treatment, and IL-1β and IL-18 levels between two groups of pediatric patients. 【Results】The swelling disappearance time and pain relief time in the observation group were shorter than those in the control group (P<0.05). Before treatment, there was no statistically significant difference in IL-1β and IL-18 levels between the two groups (P>0.05); After treatment, the levels of IL-1β and IL-18 in both groups decreased (P<0.05), and the observation group was lower than the control group (P<0.05). 2 days after surgery, the visual analog scale (VAS) scores of both groups were significantly lower than before surgery (P<0.05), and the observation group was lower than the control group (P<0.05); After 3 days of surgery, the VAS scores of both groups significantly decreased compared to preoperative and postoperative 2 days, and the observation group was lower than the control group (P<0.05). Follow up for 1 year showed that in the control group, 10 apical inflammations occurred, with a treatment success rate of 82.14%(46/56); Two apical inflammations were observed in the observation group, with a treatment success rate of 96.15%(50/52). The success rate of root canal treatment in the observation group was higher than that in the control group, and the difference was statistically significant (χ²=5.359,P=0.021). 【Conclusion】Vitapex paste root canal filling has a significant therapeutic effect on children with primary pulpitis and can reduce IL-1β and IL-18 levels , alleviate postoperative tooth pain in pediatric patients and improve the success rate of root canal treatment.

Key words： Pulpitis/TH Root Canal Obturation Interleukin-1beta Interleukin-18

Received: 20 July 2023

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R781.2

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	ZHANG Bo
	SONG Zhenzhen

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ZHANG Bo,SONG Zhenzhen. The Therapeutic Effect of Vitapex Paste Root Canal Filling in the Treatment of Pediatric Primary Pulpitis and its Impact on IL-1β and IL-18 Levels[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 504-506.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.04.007 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I4/504

[1] 贾敏,张磊. Vitapex糊剂填充对根尖周炎患者根管菌落数和血清炎症因子水平的影响[J].临床医学,2022,42(4):55-57.
[2] 康静,程玉楠,高琪. Vitapex糊剂一次性根管充填与传统方式对比结果[J].粘接,2022,49(9):115-118.
[3] 张婧,符增涛,宋紫竹. 不同根管填充材料对根尖周炎患者根管填充效果和咀嚼功能的影响[J].海南医学,2022,33(13):1706-1709.
[4] 曾宇. 不同糊剂根管填充对乳牙慢性根尖周炎患儿炎症因子水平和疼痛程度及复发情况的影响[J].当代医学,2022,28(10):130-132.
[5] 刘璐. Vitapex糊剂治疗儿童乳牙窦道型慢性根尖周炎的近远期效果[J].当代医学,2022,28(7):119-121.
[6] 胡立志. 三种根充糊剂根管填充联合冠修复治疗隐裂性牙髓病对咀嚼功能的影响[J].四川生理科学杂志,2022,44(3):419-422.
[7] 张花香. Vitapex糊剂在儿童乳牙牙髓炎中的应用效果分析[J].中外医疗,2022,41(30):90-93.
[8] 曾伟峰. Vitapex糊剂治疗乳牙窦道型慢性根尖周炎患儿的临床效果[J].医疗装备,2022,35(14):81-84.
[9] 曹馨. Vitapex糊剂充填在小儿急性牙髓炎一次性根管治疗中的应用效果[J].中国民康医学,2022,34(19):65-67.
[10] 宋戈. Vitapex糊剂与氧化锌丁香油糊剂用于乳牙根管充填的对比分析[J].基层医学论坛,2022,26(10):43-45.
[11] 王丽,淦岷,童锦发. Vitapex糊剂在小儿乳牙牙髓炎中的填充质量及对患儿牙周相关指标的影响[J].中国妇幼保健,2022,37(2):275-277.
[12] 李婷. Vitapex糊剂在儿童乳牙牙髓炎中应用效果及对牙周指标的影响[J].大医生,2022,7(17):54-56.
[13] 李妮珊. 分析牙髓根尖周病患者行不同根充糊剂治疗的疗效[J].中国医药指南,2022,20(1):104-106.
[14] 李畅. Vitapex填充糊剂联合米诺环素治疗老年慢性牙周炎伴牙髓病变的疗效观察[J].中国冶金工业医学杂志,2022,39(3):323-324.
[15] 吕辰翼,童熹,李国民,等. 复方茶多酚漱口液联合Vitapex糊剂根管填充治疗小儿乳牙慢性根尖周炎效果观察[J].中国乡村医药,2021,28(10):22-23.
[16] 李新尚,牛巧丽,程鲁晋,等. 多联抗生素糊剂与Vitapex糊剂治疗牙髓-根尖周病的疗效比较[J].医学综述,2021,27(20):4139-4142.
[17] 钟家旺,李立,朱凯. Vitapex糊剂治疗根尖周炎伴牙周炎患者的临床研究[J]. 中国临床药理学杂志,2021,37(12):1518-1520.
[18] 冯瑞. 碘仿氧化锌糊剂与Vitapex糊剂治疗小儿乳牙慢性根尖周炎的效果对比[J].当代医学,2021,27(29):115-116.
[19] 黄芳. 牙周牙髓联合病变应用经根管注射Vitapex糊剂加盐酸米诺环素软膏治疗的预后情况研究[J].中国医药科学,2021,11(20):228-231.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 126-128.