清眩解郁汤对老年高血压眩晕患者血压及Hcy、VEGF水平的影响

doi:10.3969/j.issn.1671-7171.2024.01.015

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Abstract 【Objective】 To explore the effects of Qingxuan Jieyu Decoction on blood pressure and levels of homocysteine (Hcy) and vascular endothelial growth factor (VEGF) in elderly patients with hypertension and vertigo. 【Methods】 A total of 102 elderly patients with hypertension and vertigo treated at two hospital were randomly divided into an observation group (Qingxuan Jieyu Decoction + Western medicine treatment) and a control group (Western medicine treatment), with 51 patients in each group. The therapeutic effect, adverse reactions, traditional Chinese medicine (TCM) syndrome scores, systolic blood pressure (SBP), diastolic blood pressure (DBP), dizziness assessment rating scale (DARS) scores, and levels of Hcy and VEGF before and after treatment were compared in both groups. 【Results】 The total effective rate in the observation group was 88.24%, which was significantly higher than 70.59% in the control group (P<0.05). After treatment, scores for vertigo, headache, chest tightness, irritability, palpitations, and insomnia in both groups were significantly lower than before treatment, with the observation group showing even lower scores than the control group (P<0.05). After treatment, SBP, DBP, and DARS scores in both groups were significantly lower than before treatment (P<0.05), and the observation group showed even lower scores of SBP, DBP, and DARS than the control group (P<0.05). After treatment, levels of Hcy and VEGF in both groups were significantly lower than before treatment, while levels of Hcy and VEGF in the observation group were lower than those in the control group (P<0.05). The total incidence of adverse reactions in both groups showed no significant difference (P>0.05). 【Conclusion】 Qingxuan Jieyu Decoction can effectively alleviate vertigo symptoms in elderly patients with hypertension and vertigo, control blood pressure levels, protect vascular endothelial function, and has few adverse reactions.

Key words： Hypertension/CO Vertigo/CO Hypertension/ZY Vertigo/ZY Vascular Endothelial Growth Factors/BL Cysteine/BL

Received: 16 October 2022

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R544.1

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	WANG Liang
	WANG Xiaorong

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WANG Liang,WANG Xiaorong. Effects of Qingxuan Jieyu Decoction on Blood Pressure, Homocysteine, and Vascular Endothelial Growth Factor Levels in Elderly Patients with Hypertension and Vertigo[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 54-57.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.01.015 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I1/54

[1] MCMANUS R, CONSTANTI M, FLOYD C N, et al. Managing cardiovascular disease risk in hypertension[J].Lancet,2020, 395(10227):869-870.
[2] PARFENOV V A, OSTROUMOVA T M, OSTROUMOVA O D . Hypertension and dizziness: is there a relation?[J].Rational Pharm Card,2019, 15(1):125-129.
[3] HE X, WANG Z F, HUANG Y R, et al. Treatment and exploration of integrated traditional Chinese and western medicine for hypertension[J].TMR Int Med,2022, 6(19):1-9.
[4] WANG R, DONG Y, ZHANG W, et al. Efficacy and Safety of adding and subtracting decoction of rehmanniae combined with western medicine in the treatment of hypertension:A systematic review and meta-analysis[J].Asian Toxicol Tese,2022, 4(1):7-14.
[5] 中华医学会心血管病学分会, 中国老年学学会心脑血管病专业委员会. 老年高血压的诊断与治疗中国专家共识(2011版)[J].中华内科杂志, 2012, 51(1):76-82.
[6] 梁茂新, 高天舒. 《中药新药临床研究指导原则》脏腑诸证考察与分析[J].中国中医基础医学杂志, 2008, 14(5):330-331.
[7] 孟胜喜, 霍清萍, 王兵,等. 复方恒清汤联合马来酸左旋氨氯地平治疗高血压性眩晕的临床疗效[J].中西医结合心脑血管病杂志, 2018, 16(5):528-532.
[8] 任胜洪, 石燕芳, 李青,等. 解郁平肝汤治疗高血压合并焦虑症肝郁化火型的临床观察[J].世界中医药, 2017, 12(6):1294-1297.
[9] 冯琳, 陈苏宁. 清眩解郁汤治疗高血压合并焦虑抑郁状态的临床疗效观察[J].实用药物与临床, 2018, 21(6):677-679.
[10] 高晓宇, 丁茹. 钩藤化学成分及药理作用研究进展[J].天津医科大学学报, 2017,23(4):380-382.
[11] 张翠青, 姚灿坤. 牛膝,杜仲,桑寄生治疗“肾虚态”高血压病-仝小林三味小方撷萃[J].吉林中医药, 2019, 39(12):1576-1578.
[12] YU J, ZHANG L L, WU X P, et al. Homocysteine inhibits the viability and migration ability of human umbilical vein endothelial cells by down-regulating the expression of vascular endothelial growth factor[J].Exp Ther Med,2019, 18(5):3913-3919.
[13] KOZYREVA A R, LVOVA T Y, MARKOVA K L, et al.Influence of VEGF deprivation upon vascular formation by endothelium in the presence of macrophages[J].Med Immunol,2020, 22(2):231-248.
[14] 张亭, 李伟超. 天麻素胶囊联合洛美利嗪治疗血管神经性偏头痛的临床研究[J].现代药物与临床, 2019, 34(2):327-331.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 311-313.