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| Prognostic Value of Serum NF-κB and Nrf2 Levels in Type 2 Diabetes Nephropathy |
| ZHANG Yong, WANG Xinlei |
| NO.215 Hospital of Shaanxi Nuclear Industry, Xianyang Shaanxi 712000 |
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Abstract 【Objective】To explore the prognostic value of serum levels of nuclear factor-κB (NF-κB) and nuclear factor E2 related factor (Nrf2) in patients with type 2 diabetes nephropathy.【Methods】The clinical data of 118 patients with type 2 diabetes nephropathy admitted to the NO.215 Hospital of Shaanxi Nuclear Industry from April 2020 to April 2022 were retrospectively analyzed. According to the prognosis of patients, they were divided into poor prognosis group (renal failure, uremia or death, n=48) and good prognosis group (n=70). The prognostic factors of type 2 diabetes nephropathy patients and the predictive value of NF-κB and Nrf2 on the prognosis of type 2 diabetes nephropathy patients were analyzed.【Results】The levels of NF-κB, serum creatinine (Scr), and urinary protein excretion rate (UAER) in the poor prognosis group were higher than those in the good prognosis group, while Nrf2 and glomerular filtration rate (eGFR) were lower than those in the good prognosis group (P<0.05). Logistic analysis showed that the increase of NF-κB, Scr, UAER, Nrf2 and eGFR were all risk factors for poor prognosis of type 2 diabetes nephropathy patients (P<0.05). The analysis of ROC curve of subjects showed that the area under the curve (AUC) of serum NF-κB, Nrf2 and their combination to predict the prognosis of type 2 diabetes nephropathy patients were 0.713, 0.706 and 0.801, respectively. 【Conclusion】The combination of serum NF-κB and Nrf2 is effective in predicting the prognosis of patients with type 2 diabetes nephropathy.
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Received: 26 June 2023
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2023, Vol. 40 
