急性脑梗死患者溶栓疗效的影响因素研究

doi:10.3969/j.issn.1671-7171.2023.12.023

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1282 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the factors affecting the efficacy of thrombolytic therapy in patients with Acute Cerebral Infarction (ACI). 【Methods】A retrospective analysis was conducted on the clinical data of 120 patients with ACI who underwent thrombolytic therapy in our hospital. Based on the therapeutic effect of thrombolysis, patients were divided into a good prognosis group and a poor prognosis group. Differences in relevant data between the two groups were compared, and multivariate logistic regression analysis was used to analyze the independent risk factors affecting the thrombolytic effect in ACI patients. 【Results】Out of the 120 ACI patients treated with thrombolysis, 34 cases (28.33%) had poor prognosis and were categorized into the poor group; the remaining 86 cases (71.67%) had good prognosis and were categorized into the good group. There were no significant differences between the two groups in terms of Body Mass Index (BMI), time from onset to thrombolysis, time from onset to the first Transcranial Doppler (TCD) examination, blood lipid and coagulation index levels, gender, and comorbidities (P>0.05). The age and National Institutes of Health Stroke Scale (NIHSS) scores in the poor prognosis group were higher than those in the good prognosis group (P<0.05), while the Thrombolysis in Brain Ischemia (TIBI) grading and vascular recanalization rate in the poor prognosis group were lower than those in the good prognosis group(P<0.05). Multivariate logistic regression analysis showed that TIBI grading (OR=2.658), vascular recanalization rate (OR=6.532), and NIHSS score (OR=8.712) were independent risk factors affecting the efficacy of thrombolytic therapy in ACI patients (P<0.05). 【Conclusion】TIBI grading, vascular recanalization rate, and NIHSS score are risk factors for poor prognosis in patients with ACI undergoing thrombolytic therapy.

Key words： Brain Infarction Acute Disease Thrombolytic Therapy Treatment Outcome Root Cause Analysis

Received: 07 March 2023

PACS:

R743.33

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	GUO Jing
	YANG Jinsuo
	CHAI Lihong

Cite this article:

GUO Jing,YANG Jinsuo,CHAI Lihong. Study on the Influencing Factors of Thrombolytic Therapy Efficacy in Patients with Acute Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1902-1904.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.12.023 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I12/1902

[1] 梁菊萍,杨旸,董继存. 急性脑梗死患者流行病学调查及危险因素[J].中国老年学杂志,2021,41(12):2484-2487.
[2] LIU X, RAO S, WANG J. Intravenous thrombolysis in combination with mild hypothermia therapy in the treatment of acute cerebral infarction[J].Pak J Med Sci,2019,35(4):1161-1166.
[3] 张敏,靳航,吴江. 急性前循环脑梗死静脉溶栓患者TIBI分级与血管再通和预后的相关性研究[J].中风与神经疾病杂志,2018,35(1):30-34.
[4] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[5] PATRICK L. Using the National Institutes of Health Stroke Scale[J].Stroke,2017, 48(2):513-519.
[6] 胡万保,罗祖明,商慧芳. 脑卒中4种评定量表的效度、信度及可操作性检验[J].中国临床康复,2002,6(19):2846-2867.
[7] 李兆妍,张晓曼,王军杰,等. 经颅多普勒与磁共振灌注加权成像评估急性缺血性脑卒中患者脑血流与脑灌注变化[J].中国实用神经疾病杂志,2020,23(22):1956-1960.
[8] FAHED R, MAACHA M B, DUCROUX C, et al. Agreement between core laboratory and study investigators for imaging scores in a thrombectomy trial[J].J Neurointerv Surg,2018,10(12):30.
[9] 朱云波,李佳佳,刘伟,等. 急性脑梗死静脉溶栓早期治疗效果的相关影响因素[J].中国老年学杂志,2019,39(9):2084-2087.
[10] 田轶,唐思治,罗霄鹏. 老年急性脑梗死病人静脉溶栓的治疗效果及其预后的相关因素分析[J].实用老年医学,2020,34(5):479-483.
[11] 车锋丽,陈胜云,杨中华,等. 经颅多普勒超声脑缺血溶栓分级与阿替普酶静脉溶栓治疗急性前循环不同大动脉闭塞性脑梗死预后相关性研究[J].中国卒中杂志,2017,12(4):302-308.
[12] 刘淑萍,刘淑敏,李英,等. 经颅多普勒超声对急性脑梗死溶栓后的血流评估[J].中西医结合心脑血管病杂志,2016,14(6):648-650.
[13] 潘延平,陈建玲,刘小丽. 急性前循环脑梗死静脉溶栓患者TIBI分级与血管再通和预后的相关性研究[J].贵州医药,2020,44(12):1923-1924.