|
|
|
| Correlation between Serum FPG, 2hPG, Blood Pressure and Hypothyroidism in People with Abnormal Lipid Metabolism |
| QI Hongdu, WEI Jian, WANG Xiaoyan, et al |
| Department of Endocrinology, Pucheng County Hospital, Weinan Shaanxi 715500 |
|
|
|
|
Abstract 【Objective】To analyze the correlation between serum fasting glucose (FPG), 2 h postprandial glucose (2hPG) and blood pressure levels and hypothyroidism in people with abnormal lipid metabolism. 【Methods】A total of 86 patients with abnormal lipid metabolism admitted to our hospital from March 2020 to March 2022 were selected. According to the Guidelines for the Diagnosis and Treatment of Adult Hypothyroidism, 86 patients were divided into subclinical hypothyroidism (SCH) group (TSH>4.5 mIU/L, n=38) and non hypothyroidism group (TSH ≤ 4.5 mIU/L, n=48). According to the diagnostic criteria of American Endocrine Association for SCH in 2004, the SCH group was divided into mild hypothyroidism group (n=25) and severe hypothyroidism group (n=13).Serum FPG, 2hPG, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), diastolic blood pressure (DBP) and systolic blood pressure (SBP) were measured in all subjects.The levels of FPG, 2hPG, DBP, SBP, TC, TG, LDL-C and HDL-C in patients with hypothyroidism of different degrees were compared between the two groups; The value of ROC analysis of serum FPG, 2hPG and blood pressure in predicting hypothyroidism in patients with abnormal lipid metabolism; The correlation between serum FPG, 2hPG, blood pressure and TSH level in patients with abnormal lipid metabolism was analyzed by Person coefficient. 【Results】The levels of FPG, 2hPG, DBP, SBP, TG, TC, LDL-C in the SCH group were higher than those in the non decreased group, and the HDL-C levels were lower than those in the non decreased group, with a statistically significant difference (P<0.05). The levels of FPG, 2hPG, DBP, SBP, TG, TC and LDL-C in mild hypothyroidism group were lower than those in severe hypothyroidism group, and the levels of HDL-C were higher than those in severe hypothyroidism group, with statistical significance (P<0.05). According to ROC analysis, the best cutoff values of serum FPG, 2hPG and DBP ,SBP levels for predicting hypothyroidism in patients with abnormal lipid metabolism were 5.243 mmol/L, 7.014 mmol/L, 80.050 mmHg , 128.450 mmHg. Through correlation analysis, the levels of FPG, 2hPG, DBP, SBP were positively correlated with the levels of TSH in patients with abnormal lipid metabolism (P<0.05). 【Conclusion】The levels of serum FPG, 2hPG, blood pressure and lipid metabolism indexes were significantly different between those with abnormal lipid metabolism who had hypothyroidism and those without hypothyroidism. The levels of FPG, 2hPG, DBP and SBP were significantly positively correlated with the levels of TSH in those with abnormal lipid metabolism.
|
|
Received: 02 December 2022
|
|
|
|
|
|
[1] 鲍宽烨,陈月玲,王德志,等.黄山市2012-2016年先天性甲状腺功能减低症的筛查与治疗[J].医学临床研究,2020,37(4):516-518.
[2] BARCHETTA I, DULE S, BERTOCCINI L, et al. The single-point insulin sensitivity estimator (SPISE) index is a strong predictor of abnormal glucose metabolism in overweight/obese children:a long-term follow-up study[J].J Endocrinol Invest,2022,45(1):43-51.
[3] 中华医学会内分泌学分会. 成人甲状腺功能减退症诊治指南[J].中华内分泌代谢杂志,2017,33(2):167-180.
[4] 赵水平.《中国成人血脂异常防治指南(2016年修订版)》要点与解读[J].中华心血管病杂志,2016,44(10):827-829.
[5] SURKS M I, ORTIZ E, DANIELS G H, et al. Subeclinical thyroid discase:scientifie review and guide lines for diagnosisand management[J].JAMA,2004,291(2):228-238.
[6] QUAN Z W, LIN L, LONG Y, et al. Correlation analysis of influencing factors of postpartum thyroid function in women with abnormal thyroid function during pregnancy[J].J Med Res,2020,49(9):67-71.
[7] 苗曦,王晓宇,马利双,等.合肥市某区人群亚临床甲状腺功能减退症中促甲状腺激素水平与代谢综合征发病的相关性[J].安徽医科大学学报,2022,57(8):1318-1322.
[8] 常星宇,傅松波,汤旭磊,等.脂代谢异常人群亚临床甲状腺功能减退患病率及相关因素分析[J].中国医科大学学报,2021,50(11):997-1001.
[9] 孙彦琴,贾永平,吕吉元,等.亚临床甲状腺功能减退对原发性高血压病人血压变异性的影响[J].中西医结合心脑血管病杂志,2021,19(18):3184-3188.
[10] 吴旻,潘韵峰,黄美先,等. 不同程度亚临床甲状腺功能减退对脂代谢及糖代谢影响和心血管疾病危险性分析[J].医学研究杂志,2011,40(6):127-130.
[11] 杨菊梅,李永莉.FGF-21、Apelin在妊娠合并甲减患者血清中的水平表达及其与血脂水平、低体重新生儿发生率的相关性分析[J].医学临床研究,2021,38(5):724-726.
[12] 黎雅清,张家俊,林健才. 亚临床甲状腺功能减退症对2型糖尿病患者的代谢指标及慢性并发症的影响[J].中国医学创新,2019,16(10):44-48.
[13] 王瑾,解为慈,刘文,等.糖代谢异常患者发生亚临床甲状腺功能减退症的临床特征及其相关因素[J].公共卫生与预防医学,2022,33(2):145-148.
[14] 沈自雄,傅松波,汤旭磊,等. 糖代谢异常者亚临床甲状腺功能减退症患病率及其相关因素[J].中国医科大学学报,2021,50(4):327-331.
[15] 涂燕平,雷梦觉,吴小和,等. 亚临床甲减与高血压患者C反应蛋白及尿微量白蛋白之间关系的研究[J].中国心血管病研究, 2010,8(12):909-911. |
|
|
|
2023, Vol. 40 
