认知行为疗法联合药物治疗青少年抑郁症非自杀性自伤患者的效果

doi:10.3969/j.issn.1671-7171.2023.09.012

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1145 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To explore the value of cognitive behavioral therapy (CBT) combined with medication treatment on non-suicidal self-injury (NSSI) in adolescents with depression.【Methods】Eighty non-NSSI adolescents with depression from our hospital were randomly divided into an observation group and a control group,with 40 cases in each group. The patients in the control group received medication treatment,while patients in the observation group received CBT combined with medication treatment. The therapeutic effects,occurrence of adverse reactions,Hamilton Depression Rating Scale (HAMD) scores,Self-Rating Depression Scale (SDS) scores,Self-Rating Anxiety Scale (SAS) scores,Coping Style Questionnaire (CSQ) scores,as well as levels of brain-derived neurotrophic factor (BDNF),neuropeptide Y (NPY),and serotonin (5-HT) were compared between the two groups before and after treatment.【Results】The total effective rate in the observation group was 87.50% (35/40),which was significantly higher than the control group's 67.50% (27/40),and the difference was statistically significant (P<0.05). The HAMD scores,SDS scores,and SAS scores in both groups after treatment were significantly lower than those before treatment,while these scores in the observation group were lower than those in the control group (P<0.05). There were no statistically significant differences in each factor score of the CSQ evaluation in the control group before and after treatment (P>0.05). After treatment,the scores of problem-solving and help-seeking factors in the observation group were significantly higher than those before treatment and the control group (P<0.05),the scores of avoidance and self-blame factors were significantly lower than those before treatment and the control group (P<0.05),There were no statistically significant differences in the scores of fantasy and rationalization factors in the observation group after treatment if compared to before treatment and the control group (P>0.05). The levels of BDNF,NPY,and 5-HT in both groups were significantly higher after treatment compared to before treatment (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】CBT combined with medication treatment has good effects on improving depressive symptoms,coping skills,and autonomic nervous function in NSSI adolescents with depression. It is relatively safe as well.

Key words： Depressive Disorder/DT Depressive Disorder/PX Adolescent

Received: 29 July 2022

PACS:

R749.42

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	MA Xuehong
	YANG Zongru
	HE Yanqin

Cite this article:

MA Xuehong,YANG Zongru,HE Yanqin. Effect of Cognitive Behavioral Therapy Combined with Medication Treatment on Non-Suicidal Self-Injury in Adolescents with Depression[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1324-1327.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.09.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I9/1324

[1] WHITE H V,SILAMONGKOL T,WIGLESWORTH A,et al. Maternal emotion socialization of adolescent girls engaging in non-suicidal self-injury[J].Res Child Adolesc Psychopathol,2021,5(49):683-695.
[2] AMMERMAN B A,LENGEL G J,WASHBURN J J. Consideration of clinician and researcher opinions on the parameters of nonsuicidal self-injury disorder diagnostic criteria[J].Psychiatry Res,2021,296(2):113642.
[3] 房金涛,李文秀. 抑郁障碍患者非自杀性自伤行为及其风险因素分析[J].临床精神医学杂志,2019,29(1):23-26.
[4] BROWN R C,PLENER P L. Non-suicidal self-injury in adolescence[J].Curr Psychiatry Rep,2017,19(3):20-27.
[5] 英国国家卫生与临床优化研究所. NICE 发布2015儿童及青少年抑郁症的识别和管理指南(基层版)[J].中国全科医学,2015,(24):2880.
[6] HALICKA J,KIEJNA A. Non -suicidal self-injury (NSSI) and suicidal: Criteria differentiation[J].Adv Clin Exp Med,2018,27(2):257-261.
[7] 申永辉,陈致宇,张学平,等. 血清炎症细胞因子水平与抗抑郁疗效的关系[J]. 浙江医学,2019,41(13):1370-1373.
[8] 胡诗琪,乔冬冬. 童年创伤与非自杀性自伤相关性的研究现状[J].精神医学杂志,2020,33(5):397-400.
[9] 黄俭,程小伟,朱向阳,等. 科拉奇分析法联合认知行为疗法在青少年非自杀性自伤行为中的应用及其对Barratt评分和MOAS的影响[J].实用医学杂志,2022,38(3):360-365.
[10] LIU R T,SCOPELLITI K M,PITTMAN S K,et al. Childhood maltreatment and non-suicidal self-injury: A systematic review and meta-analysis[J].Lancet Psychiat,2018,5(1):51-64.
[11] STEFAN S,CRISTEA I A,TATAR A S,et al. Cognitive-behavioral therapy (CBT) for generalized anxiety disorder : Contrasting various CBT approaches in a randomized clinical trial[J].J Clin Psychol,2019,75(7):1188-1202.
[12] 徐华,孙士银,徐冰,等. 认知行为治疗联合抗抑郁药对产后抑郁症患者的疗效[J].国际精神病学杂志,2020,47(2):297-299.
[13] 康延海,李佳,董洁,等. 氟西汀联合认知行为治疗对急性期非典型特征抑郁症疗效及负性自动思维和自杀意念的影响[J].疑难病杂志,2022,21(2):182-187.
[14] 苏邹,丁迎,陈婷婷,等. 叶酸辅助舍曲林对抑郁症患者血清脑源性神经营养因子及同型半胱氨酸的影响研究[J].中国全科医学,2019,22(27):66-71.