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| The Application Value of Combined Detection of Serum miR21,miR155-5P,and miR20a in the Early Diagnosis of Cervical Cancer |
| WANG Yan-yan, ZHONG Rong |
| Department of Gynecology, Xi'an North Hospital, Xi'an Shaanxi 710043 |
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Abstract 【Objective】To explore the application value of combined detection of serum microribonucleic acid 21 (miR21),microribonucleic acid 155-5P (miR155-5P),and microribonucleic acid 20a (miR20a) in the early diagnosis of cervical cancer. 【Methods】 A retrospective analysis was conducted on the clinical data of 41 patients with cervical cancer (cervical cancer group) and 41 patients with cervical intraepithelial neoplasia (CIN) who received treatment at the Xi'an North Hospital from May 2018 to May 2022. Two sets of baseline data and serum indicators [carbohydrate antigen-125 (CA-125),miR21,miR155-5P,and miR20a] were compared; The diagnostic value of combined detection of miR21,miR155-5P,and miR20a in cervical cancer was analyzed using the receiver operating characteristic (ROC) curve; Multiple logistic regression analysis was used to identify the risk factors for cervical cancer. 【Results】There was no statistically significant difference (P>0.05) between the two groups in terms of age,body mass index (BMI),smoking history,menopausal status,clinical staging,family history of gynecological tumors,past history of gynecological diseases,past history of sexually transmitted diseases,pregnancy,childbirth,miscarriage frequency,imaging cervical abnormalities,and serum CA-125 levels;The proportion of HPV infection,age of first sexual intercourse<20 years old,and serum levels of miR21,miR155-5P,and miR20a in the cervical cancer group were higher than those in the CIN group (P<0.05). The ROC curve analysis results show that serum miR21,miR155-5P,and miR20a can all be used for the diagnosis of cervical cancer,with areas under the curve of 0.949,0.930,and 0.889,respectively. Combined diagnosis can obtain higher areas under the curve. Multivariate logistic regression analysis confirmed that HPV infection,age of first sexual intercourse<20 years old,miR21 ≥2.285,miR155-5P ≥2.335,and miR20a ≥2.445 were all risk factors for cervical cancer. 【Conclusions】Serum miR21,miR155-5P,and miR20a are all involved in the occurrence and development of cervical cancer,and their expression is of great significance for the early diagnosis of cervical cancer; Patients with HPV infection,age of first sexual activity<20 years old,miR21 ≥ 2.285,miR155-5P ≥ 2.335,and miR20a ≥ 2.445 are risk factors for cervical cancer and should be given clinical attention.
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Received: 10 November 2022
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2023, Vol. 40 
