Abstract 【Objective】To observe the effect of gonadotropin releasing hormone agonist (GnRH-a) on natural pregnancy after laparoscopic endometriosis. 【Methods】A total of 220 endometriosis patients diagnosed and treated in our hospital from October 2016 to October 2019 were selected and divided into the control group and the observation group according to the random number table method, with 110 cases in each group. Both groups were treated with laparoscopic surgery, while patients in the observation group received GnRH-a after laparoscopic endometriois. The patients were followed up for 36 months to compare the ovarian reserve function [the number of antral follicles, ovarian volume, and anti-Mullerian hormone (AMH) level], the number of natural pregnancy cases, postoperative natural pregnancy rate, and pregnancy outcome between the two groups of patients.【Results】The number of antral follicles in the observation group at 3 months and 6 months after the operation was significantly higher than that in the control group at the same period (P<0.05). There was no significant difference in ovarian volume between the two groups (P>0.05). There were 13 cases of hot flashes and 17 cases of bone mineral loss after operation in the observation group, the incidence of adverse reactions was 27.27%. The rate of natural pregnancy in the observation group at 24 months and 36 months was significantly higher than that in the control group (P<0.05). The pregnancy delivery rate, and the full-term delivery rate in the observation group were significantly higher than those in the control group 36 months after operation (P<0.05).However, the embryo developing arrest rateshowed no significant difference during 36-month follow-up between the two groups (P>0.05). The rate of premature delivery in the observation group was lower than that in the control group (P<0.05). The AMH level in the observation group was significantly higher than that in the control group at 24 months and 36 months after operation (P>0.05). 【Conclusion】Application of GnRH-a treatment in patients after laparoscopic endometriosis can promote the recovery of ovarian reserve function, increase the rate of natural pregnancy, and reduce the risk of fetal premature delivery.
YAN Hai-yan,WANG Mei. Effect of GnRH-a Treatment on Natural Pregnancy after Laparoscopic Endometriosis[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 998-1001.
2023, Vol. 40 
