超敏肌钙蛋白I联合临床特征预测老年急性缺血性脑梗死患者短期预后的价值

doi:10.3969/j.issn.1671-7171.2023.03.008

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Abstract 【Objective】 To investigate the value of high-sensitivity troponin I ( hs-TnI) level combined with clinical characteristics in predicting the short-term prognosis of elderly patients with acute ischemic cerebral infarction. 【Methods】 The clinical data of 124 elderly patients with acute ischemic cerebral infarction were analyzed retrospectively. They were divided into the poor prognosis group (n=40) and the good prognosis group(n=84). The information of clinical data [gender,age,body mass index (BMI),smoking,drinking,hypertension,blood glucose,sleep apnea syndrome,swallowing and choking cough,atrial fibrillation,pulmonary infection],hs-TnI,NIHSS score and large area infarction level were collected. The differential information between the two groups was incorporated into the logistic model for analysis. The prognosis was taken as the dependent variable and blood glucose,sleep apnea syndrome(SAS),atrial fibrillation,pulmonary infection,hs-TnI level,NIHSS score were taken as independent variables to clarify the risk factors affecting the short-term prognosis of elderly patients with acute ischemic cerebral infarction. 【Results】 There were no significant differences in terms of gender,age,BMI,smoking,drinking,hypertension,swallowing and choking cough between the two groups (P>0.05).The proportion of blood glucose >6.1 mmol/L,SAS,atrial fibrillation,pulmonary infection in the poor prognosis group was significantly higher than that in the good prognosis group (P<0.05).The hs-TnI and NIHSS score levels in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05).The area under the poor prognosis curve (AUC) predicted by hs-TnI was 0.719,the best boundary value was 19.32 ng/mL,the sensitivity was 70.00%,and the specificity was 56.70%. Multivariate logistic regression analysis confirmed that blood glucose ≥6.10 mmol/L,SAS,atrial fibrillation,pulmonary infection,hs-TnI ≥ 19.32 ng/mL,NIHSS score ≥ 15.25 were the risk factors for poor prognosis in elderly patients with acute ischemic cerebral infarction (P<0.05).The AUC of hs-TnI combined with the poor clinical features was 0.983,with a sensitivity of 95.00% and a specificity of 92.90%.【Conclusion】 The short-term prognosis of elderly patients with acute ischemic cerebral infarction is affected by blood glucose,SAS,atrial fibrillation,pulmonary infection,hs-TnI level,NIHSS score. Clinicians should pay close attention to them and make proper intervention in time.

Key words： Brain Infarction Acute Disease Troponin I Aged Prognosis

Received: 19 May 2022

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R743.33

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	CHANG Rong
	ZHANG Jin-qiao
	GAO Pan
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CHANG Rong,ZHANG Jin-qiao,GAO Pan, et al. Value of hs-TnI Level combined with Clinical Characteristics in Predicting Short-term Prognosis of Elderly Patients with Acute Ischemic Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(3): 348-351.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.03.008 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I3/348

[1] XIN Y,SHI S,YUAN G,et al. Application of CT imaging in the diagnosis of cerebral hemorrhage and cerebral infarction nerve damage[J].World Neurosurg,2020,138(1):714-722.
[2] LIN J X,LI X T,WU G Q,et al. White matter high signals interfere with noncontrast computed tomography in the early identification of cerebral infarction[J].Cerebrovasc Dis,2020,49(2):135-143.
[3] 王金松. 急性脑梗死血清Hcy和hs-CRP的变化及与病情的相关性研究[J].中国实用神经疾病杂志,2018,21(6):619-621.
[4] SANDOVAL Y.Myocardial infarction risk stratification with a single measurement of high-sensitivity troponin Ⅰ[J].J Am Coll Cardiol,2019,74(3):271-282.
[5] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[6] 张磊,刘建民. 改良Rankin量表[J].中华神经外科杂志,2012,28(5):512.
[7] 中国高血压防治指南修订委员会.中国高血压防治指南(2010年修订版)[J].中国实用乡村医生杂志,2012,19(10):1-12.
[8] NAKAJO Y,QIANG Z,ENMI J I,et al. Early detection of cerebral infarction after focal ischemia using a new mri indicator[J].Mol Neurobiol,2018,56(6):658-670.
[9] 袁学进,孙恒亮,解啸明. 急性心肌梗死应用超敏肌钙蛋白T与肌钙蛋白Ⅰ的诊断价值研究[J].临床检验杂志,2019,8(4):1-3.
[10] 吴泳,梁雁,黄丹丹,等. 急性脑梗死病人血糖和梗死灶面积与预后的关系探讨[J].中西医结合心脑血管病杂志,2018,16(16):2414-2417.
[11] WARTENBERG K E,HENKNER J,BRANDT S,et al. Effect of recanalization on cerebral edema,long-term outcome,and quality of life in patients with large hemispheric infarctions[J].J Stroke Cerebrovasc Dis,2020,29(12):105358.
[12] 韩萍,宋丽萍,杨静文,等. 急性心肌梗死合并新发心房颤动患者住院期间临床特点及预后分析[J].北京医学,2018,40(3):197-200.
[13] 王建,谷云飞. 益心健脑汤辅助治疗对急性脑梗死并发脑心综合征患者血液流变学的影响分析[J].四川中医,2018,36(6):133-135.