Abstract 【Objective】 To investigate the expression of miR-141-3p and miR-200a in the peripheral blood of patients with ovarian cancer and their predictive value for chemosensitivity. 【Methods】 A total of 82 patients with ovarian cancer admitted to the Affiliated Hospital of Yan'an University from October 2015 to September 2020 were selected. They were divided into a non responsive group and a sensitive group based on the chemotherapy efficacy of ovarian cancer patients. The clinical data of the two groups were compared. Logistic regression analysis was used to analyze the risk factors affecting the chemotherapy sensitivity of ovarian cancer patients; The receiver operating characteristics (ROC) curves were plotted to evaluate the predictive efficacy of peripheral blood miR-141-3p and miR-200a in chemosensitivity of ovarian cancer patients using area under curve (AUC). 【Results】 Of the 82 patients with ovarian cancer in this study,27 (32.93%) had no response to chemotherapy. The proportion of patients with stage Ⅳ clinical stage,lymph node metastasis,residual tumor diameter,and miR-141-3p expression level in the non responsive group were higher than those in the sensitive group (P<0.05),while the miR-200a expression level in the non responsive group was lower than that in the sensitive group (P<0.05). Logistic regression analysis showed that clinical stage Ⅳ,expression levels of miR-141-3p and miR-200a in peripheral blood were risk factors affecting chemosensitivity in patients with ovarian cancer (OR=2.732,3.241,3.277,P<0.05). The ROC curve analysis showed that the best cutoff points for predicting chemosensitivity in ovarian cancer patients with peripheral blood miR-141-3p and miR-200a were 1.55 and 1.84,respectively,and the AUC was 0.757 and 0.790,respectively. 【Conclusion】 The expression levels of miR-141-3p and miR-200a in peripheral blood are related to chemosensitivity in patients with ovarian cancer,and can be used as important reference indicators for predicting chemosensitivity in patients with ovarian cancer.
REN Juan,YAN Li-ming,SHI Xi-mei. Expression of miR-141-3p and miR-200a in Peripheral Blood of Patients with Ovarian Cancer and their Predictive Value for Chemosensitivity[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(3): 352-355.
2023, Vol. 40 
