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| Diagnostic Value of TIMD4 in the Prognosis of Patients with CNSCLC |
| WANG Ru, ZHANG Min, LI Jun-she |
| The First Department of Hengshan District People's Hospital,Yulin Shaanxi 719199 |
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Abstract 【Objective】To investigate the diagnostic value of T cell immunoglobulin and mucin domain 4 (TIMD4) in the prognosis of patients with central non-small cell lung cancer (CNSCLC).【Methods】A total of 139 patients with CNSCLC who received treatment in our hospital from April 2015 to June 2017 were selected as the research subjects. All patients were treated with transcatheter arterial chemoembolization (TACE) combined with percutaneous radiofrequency ablation (RFA). According to the 3-year prognosis,patients were divided into the survival group and the death group. Mononuclear cells were isolated by Ficoll density gradient centrifugation method. Western blotting was used to detect the expression level of TIMD4 in mononuclear cells,and the diagnostic value of TIMD4 in the prognosis of CNSCLC patients was analyzed. 【Results】The expression level of TIMD4 in the survival group and the death group showed a decreasing trend over time (P<0.05). The expression levels of TIMD4 at T1 and T2 in the survival group were lower than those in the death group,and the differences were statistically significant (P<0.05). The median survival time of the high TIMD4 group was lower than that of the low TIMD4 group; And the difference was statistically significant (P<0.05). COX regression analysis showed that TNM staging and T2-TIMD4 were independent risk factors for the prognosis of CNSCLC patients (P<0.05),while the differentiation degree and taking targeted drugs were independent protective factors for the prognosis of CNSCLC patients (P<0.05). The fitting curve of the nomogram regression model constructed by TNM staging,degree of differentiation,taking targeted drugs and T2-TIMD4 had a higher degree of coincidence with the ideal curve,whose consistency index C-index was 0.803. 【Conclusion】High TIMD4 expression in CNSCLC patients indicates a high risk of poor prognosis. The nomogram regression model based on TIMD4 has high accuracy and discrimination,which can evaluate the prognosis of CNSCLC patients.
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Received: 08 March 2022
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2023, Vol. 40 
