|
|
|
| Expression and Significance of Serum Gastrin, Motilin and Leptin in Patients with Gastroesophageal Reflux after Esophageal Cancer Stent Implantation |
| JIU Meng-na, ZHANG Yi |
| Department of Gastroenterology,Ankang Central Hospital,Ankang Shaanxi 725000 |
|
|
|
|
Abstract 【Objective】To investigate the expression and significance of serum gastrin (GAS), motilin (MTL) and leptin (LEP) in patients with gastroesophageal reflux after esophageal cancer stent implantation. 【Methods】The clinical data of 214 patients with esophageal cancer who received stent implantation in our hospital from January 2019 to January 2022 were analyzed retrospectively. General data such as serum GAS, MTL and LEP were collected to analyze the occurrence of postoperative gastroesophageal reflux. Single factor and multi factor logistic regression were used to analyze the risk factors of secondary gastroesophageal reflux after esophageal cancer stent implantation. 【Results】Gastroesophageal reflux after esophageal cancer stent implantation was significantly correlated with hyperlipidemia history, low semi sitting position, high sugar and high fat diet, regular drinking of strong tea, moderate exercise, taking NSAIDs, constipation and serum GAS, MTL, LEP (P<0.05). The history of hyperlipidemia, high sugar and high-fat diet, regular drinking of strong tea, taking NSAIDs, constipation, preoperative GAS<108.00 pg/mL, preoperative MTL<213.28 pg/mL, and preoperative LEP ≥ 15.24 ng/mL were independent risk factors for gastroesophageal reflux after esophageal cancer stent implantation (P<0.05); Sleeping posture in low semi sitting position and proper exercise were independent protective factors for postoperative gastroesophageal reflux (P<0.05). 【Conclusion】 The serum GAS, MTL and LEP are closely related to the secondary gastroesophageal reflux after esophageal cancer stent implantation. The abnormal decrease of serum GAS, MTL and the abnormal increase of serum LEP are independent risk factors for the secondary gastroesophageal reflux after esophageal cancer stent implantation, which is worthy of clinical verification.
|
|
Received: 01 July 2022
|
|
|
|
|
|
[1] 梁爱玲.艾迪注射液辅助3D-CRT治疗晚期食管癌患者的临床疗效[J].医学临床研究,2022,39(48):1242-1245.
[2] 吴沛瑶,李全朋,王飞,等.食管支架置入术和内镜下切开术治疗难治性食管癌术后吻合口狭窄的疗效比较[J].医学研究生学报,2019,32(6):591-595.
[3] 丁瑜,李伟,李彬,等.光动力疗法与食管支架置入术改善中晚期食管癌所致吞咽困难的对比分析[J].中华医学杂志,2020,100(5):378-381.
[4] DEMEESTER S R.Laparoscopic hernia repair and fundoplication for gastroesophageal reflux disease[J].Gastrointest Endosc Clin N Am,2020,30(2):309-324.
[5] 沈奕,李兴华,钟捷,等.胃食管反流病调查问卷的诊断价值评价[J].中国临床医学,2013,20(4):541-543.
[6] OZDOGAN M,KUVVETLI A,DAS K,et al.Effect of preserving the hepatic vagal nerve during laparoscopic Nissen fundoplication on postoperative biliary functions[J].World J Surg,2013,37(5):1060-1064.
[7] 王军民,朱新影,赵文娟.分节顺应性全腹膜可回收食管支架与传统食管支架用于食管恶性狭窄的前瞻性对比研究[J].中华消化内镜杂志,2020,37(7):507-509.
[8] MARET-OUDA J,MARKAR S R,LAGERGREN J.Gastroesophageal reflux disease:a review[J].JAMA,2020,324(24):2536-2547.
[9] MITTAL R,VAEZI M F.Esophageal motility disorders and gastroesophageal reflux disease[J].N Engl J Med,2020,383(20):1961-1972.
[10] SHARMA P,YADLAPATI R.Pathophysiology and treatment options for gastroesophageal reflux disease:looking beyond acid[J].Ann N Y Acad Sci,2021,1486(1):3-14.
[11] OTAKI F,IYER P G.Gastroesophageal reflux disease and barrett esophagus in the elderly[J].Clin Geriatr Med,2021,37(1):17-29. |
|
|
|
2022, Vol. 39 
