不同营养支持方案对食管癌患者同步放化疗期间不良反应的影响

doi:10.3969/j.issn.1671-7171.2022.08.025

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Abstract 【Objective】To investigate the effects of different nutritional support programs on adverse reactions during concurrent chemoradiotherapy in patients with esophageal cancer.【Methods】A total of 96 patients with esophageal cancer treated in our hospital were randomly divided into the observation group and the control group,with 48 cases in each group. The patients in the control group were given oral nutrients in addition to regular diet,and the patients in the observation group were given enteral nutrition support in addition to routine diet. The treatment effect,adverse reactions during treatment,body mass index (BMI),subjective global assessment scale (PG-SGA) score,serum albumin (ALB),hemoglobin (Hb),serum transferrin (TF) and T lymphocyte (CD4⁺,CD8⁺,CD4⁺/CD8⁺) levels before and after treatment were compared between the two groups.【Results】There was no significant difference in the effective rate of treatment between the two groups (P>0.05). After treatment,the BMI and PG-SGA score in the observation group were higher than those before treatment. The BMI in the control group was lower than that before treatment,and the PG-SGA score in the control group was higher than that before treatment (P<0.05). After treatment,the BMI of the observation group was higher than that of the control group,and the PG-SGA score was lower than that of the control group (P<0.05).The levels of ALB,Hb and TF in the observation group after treatment were higher than those before treatment,and those in the control group were lower than those before treatment (P<0.05). After treatment,there were no significant differences in CD4⁺,CD8⁺,CD4⁺/CD8⁺ in the observation group compared with those before treatment (P>0.05). Both CD4⁺ and CD4⁺/CD8⁺ in the control group were lower than those before treatment and the observation group (P<0.05),and there was no significant difference in CD8⁺ among those comparisons (P>0.05). The incidences of infection and myelosuppression≥grade 3 in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the incidence of radiation pneumonitis≥grade 3 and radiation esophagitis≥grade 3 between the two groups (P<0.05).【Conclusion】Enteral nutrition support program for patients with esophageal cancer during concurrent radiotherapy and chemotherapy can improve nutritional status,enhance immune function,reduce the incidence of infection and myelosuppression,and improve radiotherapy and chemotherapy tolerance.

Key words： Esophageal Neoplasms/DT Esophageal Neoplasms/RT Nutritional Support Drug-Related Side Effects and Adverse Reactions Radiotherapy/AE

Received: 20 March 2022

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R735.1

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.08.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I8/1213

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