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| Efficacy of OXA Regimen in the Treatment of Elderly Patients with Advanced Primary Liver Cancer and its Effect on Serum D-dimer and CyclinD Protein |
| LIU Huan, WANG Feng-wen, LUO Shu-ping, et al |
| Department of Hepatobiliary Surgery,Shandong Provincial Third Hospital,Jinan Shandong 250031 |
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Abstract 【Objective】 To investigate the efficacy of oxaliplatin (OXA) regimen in the treatment of elderly patients with advanced primary liver cancer and its effect on serum D-dimer and CyclinD protein. 【Methods】A total of 26 patients with advanced primary liver cancer were treated in our hospital as the observation group,and 120 healthy persons in the same period as the control group. The efficacy of oxa regimen after 1,2 and 3 courses of treatment and the expression levels of D-dimer,fibrinogen,fibrinogen degradation products (FDP),CyclinD and heat shock protein 70 (HSP70) in the serum of the two groups were compared,and the adverse reactions and long-term efficacy of chemotherapy were counted. 【Results】After treatment,with the increase of the course of treatment,the proportion of complete remission and partial remission increased significantly,and there was significant difference in each course of treatment (P<0.05). Before treatment,the indexes of the observation group were significantly higher than those of the control group,and the difference was statistically significant (P<0.05). After treatment,the expression levels of D-dimer,fibrinogen,FDP,CyclinD and HSP70 in serum of patients with advanced liver cancer were significantly lower than those before treatment (P<0.05),and with the extension of treatment time,the levels of various indicators showed a gradual downward trend (P<0.05). One patient had nausea and vomiting,one had hematological toxicity and one had peripheral neurotoxicity during chemotherapy. The total adverse reaction rate was 11.54% (3/26). After 1 year follow-up,4 patients had recurrence or metastasis,and the median progression free survival was 7 months. 【Conclusion】 OXA regimen has obvious effect on elderly patients with advanced primary liver cancer,which may be related to the expression of D-dimer and CyclinD protein in serum.
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Received: 14 December 2021
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2022, Vol. 39 
