Abstract 【Objective】 To investigate the changes of serum fibrinogen (FiB),D-dimer (D-D),soluble vascular endothelial growth factor receptor-1 (sFlt-1) and von willebrand factor (vWF) levels and their clinical significance in children with henoch-schonlein purpura nephritis (HSPN). 【Methods】 A total of 56 children with HSPN admitted to our hospital were selected as the HSPN group,79 children with henoch schonlein Purpura (HSP) were selected as the HSP group,and 52 healthy children were selected as the control group. The levels of FiB,D-D,sFlt-1,vWF,24 h urinary protein excretion (24hUPE),urea nitrogen (BUN) and serum creatinine (SCr) in all groups were detected and compared. Pearson correlation method was used to analyze the correlation of FiB,D-D,sFlt-1 and vWF with renal injury indexes. 【Results】The FiB,D-D,sFlt-1 and vWF levels in the HSPN group were significantly higher than those in the HSP group and the control group (P<0.05),and the levels of FiB,D-D,sFlt-1 and vWF in the HSP group were significantly higher than those in the control group (P<0.05). The level of 24hUPE in the HSPN group was significantly higher than that in the HSP group and the control group (P<0.05),while there was no statistical difference in 24hUPE level between the HSP group and the control group (P>0.05). There were no statistical differences in BUN and SCr levels among all groups (P>0.05). Pearson correlation analysis showed that there was no significant correlation between FiB and 24hUPE in the HSPN group (r=0.188,P>0.05),while D-D,sFlt-1 and vWF were positively correlated with 24hUPE (r=0.491,0.502,0.546,P<0.05). 【Conclusion】The levels of FiB,D-D,sFlt-1 and vWF in the HSPN children were significantly increased,which may be associated with early renal injury of HSP.
ZHANG Ying-xu,FAN Shu-juan. Clinical Significance of Serum FiB,D-D,SFLT-1 and vWF Levels Changes in Children with Purpura Nephritis[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 1033-1036.
[1] LEUNG A K C,BARANKIN B,LEONG K F. Henoch-schönlein purpura in children: an updated review[J].Curr Pediatr Rev,2020,16(4):265-276.
[2] JANG H M,BAEK H,HAN M H,et al. Activation of complement system in henoch-schönlein purpura nephritis[J].Fetal Pediatr Pathol,2022,41(1):29-36.
[3] LUO X,TAN J,WAN D,et al. Predictability of the oxford classification of IgA nephropathy in henoch-schönlein purpura nephritis[J].Int Urol Nephrol,2022,54(1):99-109.
[4] 程凯,袁丽萍,胡波. 血清促胃液素、C-反应蛋白、D-二聚体检测在儿童腹型过敏性紫癜中的临床意义[J].中华实用儿科临床杂志,2019,34(11):827-831.
[5] DENIS C V,SUSEN S,LENTING P J. von Willebrand disease: what does the future hold?[J].Blood,2021,137(17):2299-2306.
[6] 中华医学会儿科学分会肾脏学组. 紫癜性肾炎诊治循证指南(2016)[J].中华儿科杂志,2017,55(9):647-651.
[7] 中华医学会儿科学分会免疫学组,《中华儿科杂志》编辑委员会. 儿童过敏性紫癜循证诊治建议[J].中华儿科杂志,2013,51(7):502-507.
[8] AL E'ED A. Henoch-Schönlein purpura in Saudi Arabia: characteristics and rare vital organ involvement[J].Minerva Pediatr (Torino), 2021,73(4):363-370.
[9] IRABU H,SHIMIZU M,KANEKO S,et al. Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and henoch-schönlein purpura nephritis[J].Pediatr Res,2021,89(3):667-672.
[10] SU Q,JIANG L,CHAI J,et al. Changes of peripheral blood lymphocyte subsets and immune function in children with henoch-schönlein purpura nephritis[J].Iran J Immunol,2021,18(3):259-267.
[11] 郭凯,马曙轩,汪德清,等. 血栓弹力图与常规凝血试验对过敏性紫癜患儿凝血功能的评价及对比分析[J].中国实验血液学杂志,2019,27(3):877-886.
[12] 李婧,高成龙,吴捷. 以腹型为首发表现的儿童过敏性紫癜临床分析[J].中国实用儿科杂志,2021,36(1):47-52.
[13] 阮小霞,罗冲,安云飞,等. 过敏性紫癜患儿血清高迁移率族蛋白B1表达及意义[J].中国实用儿科杂志,2021,36(7):503-507.
[14] JELUSIC M,SESTAN M. IgA vasculitis or henoch-schönlein purpura: genetics and beyond[J].Pediatr Nephrol,2021,36(8):2149-2153.
[15] 王和平,刘光莲. IL-6、sFlt-1、VEGF在妊娠期高血压孕妇血清中的表达及其临床意义[J].医学临床研究,2021,38(5):656-658.
[16] DRÖGE L A,PERSCHEL F H,STÜTZ N,et al. Prediction of preeclampsia-related adverse outcomes with the sflt-1 (soluble fms-like tyrosine kinase 1)/PlGF (placental growth factor)-ratio in the clinical routine: a real-world study[J].Hypertension,2021,77(2):461-471.
[17] PATMORE S,DHAMI S P S,O'SULLIVAN J M. Von Willebrand factor and cancer,metastasis and coagulopathies[J].J Thromb Haemost,2020,18(10):2444-2456.
2022, Vol. 39 
