替罗非班不同给药策略辅助PCI术对急性前壁心肌梗死患者心肌灌注水平、心电图改善情况及炎症因子水平的影响

doi:10.3969/j.issn.1671-7171.2022.05.015

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Abstract 【Objective】 To explore effects of different administration strategies of tirofiban assisted PCI (percutaneous coronary intervention) on postoperative myocardial perfusion level, electrocardiogram performance, the incidence of major adverse cardiovascular events (MACE) and inflammatory factors such as soluble vascular cell adhesion molecule-1 (sVCAM-1) and platelet activating factor (PAF) in patients with of acute anterior myocardial infarction. 【Methods】 Clinical data of 96 patients with acute anterior myocardial infarction in Xi'an Gaoxin hospital were retrospectively analyzed and divided into the observation group and the control group by random number table, with 48 cases in each group. Both groups were given coronary thrombus aspiration and PCI. While the control group was given tirofiban intravenously and the observation group was given tirofiban catheter injection. Patients in the two groups were compared by myocardial perfusion level post-operation, ECG performance (ST-segment fall range and Tp-e/QT), adverse reactions and MACE incidence rates immediately after surgery, and myocardial injury indexes before and after surgery [creatine phosphokinase isoenzyme (CK-MB), troponin I (cTnI), brain natriuretic peptide (BNP), lactate dehydrogenase (LDH), creatine kinase (CK)], inflammatory injury indicators [sVCAM-1, soluble CD40L (sCD40L), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α)].【Results】 The improvement of immediate myocardial perfusion in the observation group was better than that of the control group (P<0.05).The good rate of ST segment fall in the observation group within 2 hours was higher than that of the control group (P<0.05). The Tp-e/QT values of the two groups after treatment were lower than those before treatment; And value of Tp-e/QT in the observation group was lower than that in the control group (P<0.05). After treatment, CK-MB, cTnI, BNP, LDH, CK, sVCAM-1, sCD40L, CRP and TNF-α in the observation group were lower than those before treatment. And the levels of the observation group were lower than those of the control group (P<0.05). The difference in the total incidence of adverse reactions and MACE at 3 months after treatment in the two groups was not statistically significant (P>0.05). 【Conclusion】 Compared with tirofiban intravenous infusion, catheter injection of tirofiban can significantly improve myocardial perfusion in patients with coronary thrombus aspiration + PCI, optimize ECG performance and adjust sVCAM-1 and PAF levels, which has certain safety.

Key words： Anterior Wall Myocardial Infarction Angioplasty, Balloon, Coronary Platelet Glycoprotein GPⅡb-Ⅲa Complex/TU Electrocardiography

Received: 10 September 2021

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R542.22

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	LIU Yan
	BAI Guang-ming

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LIU Yan,BAI Guang-ming. Effects of Different Administration Strategies of Tirofiban Assisted PCI on Myocardial Perfusion Level, Electrocardiogram Performance and Inflammatory Factors in Patients with Acute Anterior Myocardial Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 693-696.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.05.015 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I5/693

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