Abstract 【Objective】 To detect the proportion of CD177+ neutrophils in patients with myelodysplastic syndrome (MDS) and explore its clinical significance. 【Methods】 A total of 100 MDS patients who were treated continuously in the Hematology Department of our hospital were selected. According to the MDS International Prognostic Scoring System (IPSS) risk, MDS patients were divided into the low-risk cases (n=63) and the high-risk cases (n=37).Furthermore, according to the severity of anemia, they were divided into normal hemoglobin (Hb) group (n=11), mild anemia group (n=23), moderate anemia group (n=42) and severe anemia group (n=24).In addition, 50 healthy vounteers who underwent physical examination during the same period were selected as the control group. The expression of CD177+ in neutrophils was detected by flow cytometry. Kaplan Meier method was used to analyze the relationship between the proportion of CD177+ neutrophils and the prognosis of MDS patients. Cox regression model was used to analyze the prognostic factors of MDS patients. 【Results】 The level of CD177+ neutrophils in the peripheral blood of MDS patients was significantly higher than that of the normal control group (P<0.05).Compared to those with normal hemoglobin, the levels of CD177+ neutrophils in MDS patients of moderate anemia group and severe anemia group were significantly increased (P<0.05), while there was no significant difference in the level of CD177+ neutrophils between MDS patients of mild anemia group and normal hemoglobin group (P>0.05). The levels of CD177+ neutrophils in MDS patients in mild anemia group, moderate anemia group and severe anemia group were increased in turn, and the differences were statistically significant (P<0.05). The level of CD177+ neutrophils was also related to the hemoglobin, platelet, chromosome and risk classification of IPSS (P<0.05). The 3 years cumulative survival rate of patients with myelodysplastic syndrome in the high CD177+ neutrophil level group was significantly lower than that in the low level group (35.11% vs 53.93%, P<0.05). Chromosomal abnormality and high level of CD177+ neutrophils were independent risk factors for poor prognosis of MDS (P<0.05). 【Conclusion】 The level of CD177+ neutrophils in the peripheral blood of MDS patients significantly increased, which is an independent risk factor for the prognosis of MDS patients
DENG Lei,ZHAO Yue. Clinical Significance of CD177+ Neutrophils Proportion from Peripheral Blood in Patients with Myelodysplastic Syndrome[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 697-700.
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2022, Vol. 39 
