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| Effects of Different Doses of Suixin Capsule on TrxR Activity and ATP and ADP Levels in Rats with Chronic Heart Failure |
| GUO Dian-long, GONG Zhao-wei, NING Yi, et al |
| The First People's Hospital of Xianyang , Xianyang Shaanxi, 712000 |
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Abstract 【Objective】 To investigate the effects of different doses of Suixin Capsule on the activity of thioredoxin oxidoreductase (TrxR) and the levels of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) in rats with chronic heart failure. 【Methods】 A total of 44 SPF and healthy male SD rats was randomly divided into control group, western medicine group, low-dose group and high-dose group, with 11 rats in each group. The rats in the control group were fed with animal feed under normal environment. The models of chronic heart failure were established by ligating the left anterior descending coronary artery in the western medicine group, low-dose group and high-dose group. After the successful establishment of the model, the rats were fed for 8 weeks. After the 8th week, the western medicine group was fed with captopril, the low-dose group was fed with Suixin capsule 20g/kg, the high-dose group was fed with Suixin capsule 40g/kg, and the three groups were fed once a day for 12 weeks. The left ventricular end diastolic diameter (LVDD), left ventricular end systolic diameter (LVSD), left ventricular posterior wall thickness (LVP-WT), ventricular septal thickness (IVST) and left ventricular ejection fraction (LVEF) were compared. The levels of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) in myocardial tissue and thioredoxin reductase (TRx) and thioredoxin reductase (TrxR) in liver tissue were compared Level. 【Results】 LVED, LVEDS , LVP-WT and IVST in the control group and high-dose group were lower than those in the low-dose group and Western medicine group, and LVEF levels in the control group and the high-dose group were higher than those in the low-dose group and the Western medicine group (P<0.05). The contents of ATP and ADP in myocardial tissue and the levels of TRx and TrxR in liver in the control group and high-dose group were significantly higher than those in the low-dose group and the Western medicine group (P<0.05). 【Conclusion】 Suixin capsule can be used to treat rats with chronic heart failure, improve cardiac function, TRX system and cardiomyocyte energy.
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Received: 01 August 2021
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2021, Vol. 38 
