|
|
|
| Analgesic Effect of Selective Cyclooxygenase-2 Inhibitor on Type I Incision in Laparoscopic Cholecystectomy |
| CHEN Hong, LIU Lei |
| Hanzhong Central Hospital,Hanzhong 723000,Shaanxi |
|
|
|
|
Abstract 【Objective】 To study the value of selective cyclooxygenase-2 inhibitors in perioperative patients undergoing laparoscopic cholecystectomy with type I incision. 【Methods】 A total of 84 patients with gallstone underwent laparoscopic cholecystectomy type I incision were selected. According to the different methods of perioperative pain relief, they were divided into observation group and control group, 42 cases respectively. The patients in the observation group were treated with selective cyclooxygenase-2 inhibitors (celecoxib and perrickib sodium) during the perioperative period. The control group took routine analgesia, compared the postoperative pain, the expression of COX-2, PGE2 and the incidence of adverse reactions.【Results】 At 12 h, 24 h and 48 h after operation, the VAS score of the two groups was significantly higher than that before operation, and the observation group was lower than that of the control group, the differences were statistically significant (P<0.05). Immediately after operation and 48 hours after operation, the levels of PGE2 and COX-2 in the two groups were significantly lower than those before operation. The levels of PGE2 and COX-2 in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 9.52% (4/42), which was lower than 14.29% (6/42) in the control group, but the difference was not statistically significant (χ2=0.454,P=0.500>0.05).【Conclusion】 Selective cyclooxygenase-2 inhibitor has good analgesic effect and high safety in patients with type I laparoscopic cholecystectomy incision.
|
|
Received: 18 September 2019
|
|
|
|
|
|
[1] 冯爱芳, 程亚丽, 郑鑫,等. 双镜联合微创手术与开腹手术治疗胆道结石术后疼痛及预后对照研究[J].陕西医学杂志, 2017, 46(9):1235-1236.
[2] 任磊, 沈生军, 催乃荣,等. 塞来昔布联合帕瑞昔布钠超前镇痛用于腰椎后路融合手术后多模式镇痛的效果观察[J].河北医学, 2017, 23(8):1352-1356.
[3] 高继林, 范懿隽, 卫兵. 帕瑞昔布联合塞来昔布在妇科腹腔镜手术围手术期的应用[J].安徽医学, 2015, 36(6):663-666.
[4] 谢志进. 外科手术围术期镇痛的研究进展[J].实用医院临床杂志, 2018, 15(5):247-250.
[5] 吴志强, 王卫东, 刘清波. 腹腔镜与开腹胆囊切除术治疗急性结石性胆囊炎的临床疗效对比[J].实用医学杂志, 2017, 33(13):2173-2175.
[6] 朱志威, 张代君, 高成杰. 硬膜外与静脉自控镇痛在剖宫产术后镇痛效果比较及其对母乳喂养的影响[J].中国妇幼健康研究, 2017, 28(6):667-669.
[7] 杨体敏, 斯海波, 吴元刚,等. 帕瑞昔布+塞来昔布在全膝关节置换术后的序贯应用及疗效观察[J].中国矫形外科杂志, 2017, 417(7):577-583.
[8] 张涛.塞来昔布对颅脑创伤后大鼠的凋亡蛋白Bcl-2和Bax表达影响[J].中国临床药理学杂志, 2017, 33(9):813-816.
[9] 张辉,陈俊,陈帅,等. 帕瑞昔布钠不同给药时机对THA患者超前镇痛的效果分析[J].重庆医学, 2017, 46(18):53-54.
[10] 陈美婷, 金保, 裴丽坚,等. 选择性COX-2抑制剂在开腹肝脏术后镇痛的应用[J].中国普通外科杂志, 2018, 27(1):87-93.
[11] 仇晓娟, 陈锴, 胡彬,等. 帕瑞昔布钠在术后镇痛中应用的研究进展[J].现代生物医学进展, 2018, 18(2):385-388.
[12] 王国栋,杨凌云,何斌.塞来昔布联合双醋瑞因治疗老年退行性膝骨关节炎的有效性及安全性:随机对照临床试验方案[J].中国组织工程研究, 2017, 21(36):5747-5751. |
|
|
|
2021, Vol. 38 
