|
|
|
| Correlation between Expression of S-phase Kinase Associated Protein,p27kip1 Protein and Clinicopathological Features of Gastric Cancer |
| LIU Fu, MA Pei, WEI Hai |
| The First Department of Gastrointestinal Surgery, Nanyang First People's Hospital, Nanyang, Henan 473000 |
|
|
|
|
Abstract 【Objective】 To investigate the relationship between the expression of S phase kinase-related protein (skp2) and p27kip1 protein in primary gastric cancer and the development of tumorigenesis. 【Methods】 A total of 60 cases of gastric cancer tissue samples obtained in our hospital were selected as gastric cancer group, and 60 cases of gastric cancer adjacent tissue samples were selected as control group. The positive expression rates of Skp2 and p27kip1 were detected by immunohistochemistry.The positive rates of Skp2 protein and p27kip1 Protein in gastric cancer tissues with different lesion size, histological grade, degree of invasion, lymph node metastasis and TNM stage were analyzed. 【Results】 The positive expression rate of Skp2 protein in the gastric cancer group was 68.33% (41/60), which was higher than 23.33% (14/60) in the control group; the positive expression rate of p27kip1 Protein in the gastric cancer group was 28.33% (17/60), which was lower than 73.33% (44/60) in the control group, and there was significant difference between the two groups (P<0.05); the positive expression rate of Skp2 protein in gastric cancer tissues with different TNM stages, lymph node metastasis, histological differentiation and tumor invasion was significantly different (P<0.05); the positive expression rate of Skp2 protein in gastric cancer tissues with different TNM stages and lymph node metastasis was significantly different (P<0.05).【Conclusion】 The expression of Skp2 protein is up-regulated and p27kip1 Protein is down regulated in gastric cancer, which may be related to the occurrence and development of gastric cancer.
|
|
Received: 17 November 2019
|
|
|
|
|
|
[1] SONG P, WU L, GUAN W. Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis[J].Nutrients,2015,7(12):9872-9895.
[2] 孙雅静. Skp2在恶性肿瘤的发生及治疗中的研究进展[J].国际免疫学杂志,2018,41(5):586-590.
[3] 巩波,马松炎. 胃癌患者胃黏膜组织中CDC25A、CerbB-2及P27的表达及作用机制分[J].中国中西医结合消化杂志,2019,29(3):211-214.
[4] 梁寒,张李. 早期胃癌治疗方式合理选择:争议与共识[J].中国实用外科杂志,2019,39(5):424-427.
[5] 惠双,郭宏强.晚期胃癌患者XELOX 方案化疗后维持治疗的疗效及预后生存分析[J].癌症进展,2017,15(7):780-783.
[6] KIM G M, KIM S J, SONG S K, et al. Prevalence and prognostic implications of psychological distress in patients with gastric cancer[J].BMC Cancer,2017,17(1):90-97.
[7] 刘庆滨,陈艳昕,黄江梅. 胃癌组织CDK7和SKP2的表达变化及意义[J].山东医药,2015,55(9):54-55.
[8] 吴梦莞,郭丽红,左强. p27kipl蛋白与胃癌曲妥珠单抗耐药的相关性[J].中南大学学报(医学版),2016,41(5):471-476.
[9] 李元春,何静,张浩民,等. VEGF、CD44v6及p27在胃癌组织中的表达及其临床意义[J].中国老年学杂志,2015,35(17):4881-4883.
[10] 胡泓,龚柳,孙季萍. 老年胃癌患者血清肿瘤标志物及细胞因子的表达及意义[J].中国老年学杂志,2018,38(6):1357-1359. |
|
|
|
2021, Vol. 38 
