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| Effects of Sevoflurane Anesthesia on Inflammatory and Oxidative Stress Indexes in Patients with Lung Cancer Undergoing Radical Operation |
| ZHANG Xiao-yong, HAN Jing-tian, HAN Yao-ming |
| Liaoning Health Industry Group Fukuang General Hospital,113008 |
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Abstract 【Objective】 To investigate the effect of sevoflurane anesthesia on inflammatory and oxidative stress indexes in patients with lung cancer undergoing radical operation.【Methods】 A total of 90 patients with lung cancer were randomly divided into two groups, 45 cases in each group; the observation group was given sevoflurane and maintained anesthesia, and the control group was given propofol and maintained anesthesia. The operation time, recovery time, extubation time, spontaneous breathing recovery time, hospital stay, serum E-selectin, soluble interleukin-2 receptor (SIL-2), high mobility group box 1 (HMGB1), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), malondialdehyde (MDA) and superoxide dismutase (SOD) were recorded and compared between the two groups Matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9(MMP-9)levels were recorded and compared between the two groups.【Results】 The recovery time, extubation time and spontaneous breathing recovery time of the observation group were shorter than those of the control group (P<0.05), and there was no significant difference in the operation time and hospitalization time between the two groups (P>0.05); before operation, there was no significant difference in the serum E-selectin, sIL-2, HMGB1, TNF-α, IL-6 and MDA, SOD, MMP-2, MMP-9 levels between the two groups (P>0.05); 24 hours after operation, the observation group had no significant difference The levels of serum E-selectin, sIL-2, HMGB1, TNF-αand IL-6 in the observation group were lower than those in the control group (P<0.05); the levels of serum MMP-2, MMP-9 and MDA in the observation group were lower than those in the control group (P<0.05), and the level of SOD in the observation group was higher than that in the control group (P<0.05). 【Conclusion】 Sevoflurane anesthesia in radical operation of lung cancer can reduce the inflammatory reaction and oxidative stress reaction.
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Received: 17 April 2019
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2021, Vol. 38 
