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| Relationship between Pulmonary Infection and PCT, sTREM-1 and hs-CRP Levels in Patients with NSCLC |
| WANG Cai-rong, YU Xue-wen |
| Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi, 718500, China |
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Abstract 【Objective】To study the relationship between pulmonary infection and levels of procalcitonin (PCT), myeloid trigger receptor (sTREM-1) and hypersensitive C-reactive protein (hs-CRP) in patients with non-small cell lung cancer (NSCLC). 【Methods】A total of 37 cases of NSCLC patients who received surgical treatment in our hospital and developed postoperative pulmonary infection were selected as the study subjects, and were set as the pulmonary infection group. In addition, 37 cases of NSCLC patients who did not show postoperative pulmonary infection were set as the non-pulmonary infection group.Serum PCT, sTREM-1 and hs-CRP were detected in both groups after blood samples were collected 24h after surgery. ROC curve was used to analyze the value of serum PCT, sTREM-1 and hs-CRP in predicting postoperative pulmonary infection in NSCLC patients. Logistic regression was used to analyze whether PCT, sTREM-1 and hs-CRP were risk factors for postoperative pulmonary infection in NSCLC patients. 【Results】The levels of PCT, sTREM-1 and hs-CRP in the lung infection group were significantly higher than those in the non pulmonary infection group (P<0.05). The lower curve areas of PCT, sTREM-1 and hs-CRP were 0.829, 0.738 and 0.955 respectively by ROC analysis. Logistic regression analysis showed that PCT>4.715, sTREM-1 > 4.410, hs-CRP>8.245 were risk factors of postoperative pulmonary infection in NSCLC patients. 【Conclusion】The high expression of PCT, sTREM-1 and hs-CRP in NSCLC patients with postoperative pulmonary infection is a risk factor of postoperative pulmonary infection.
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Received: 25 October 2019
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2020, Vol. 37 
