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| Study on the Influencing Factors of Anemia in 387 Premature Infants |
| ZHANG Li, SHEN Jian-jia, WANG Xiao-li |
| Department of Neonatology,Shanghai Jiading Maternal and Child Health Care Hospital,Shanghai 201801,China |
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Abstract 【Objective】 To investigate the major risk factors in the development of anemia among premature infants (gestational age <37 weeks) in hospital. 【Methods】 The medical data of 571 premature infants admitted to our department of neonatology from Janurary 2016 to December 2017 were retrospectively reviewed. There were 387 premature infants included in the study after excluding 36 cases of congenital anemia and 148 cases of short hospitalization with only one blood collection. According to complication with anemia or not,all 387 infants were divided into two groups: anemia group and non-anemia group.At the same time, data on birth weight, gestational age at birth, comorbidities, basal hemoglobin (HB) level, blood volume collected during hospitalization, and maternal hemoglobin value at the end of pregnancy were collected to analyze the related high-risk factors associated with anemia of prematurity during hospitalization. 【Results】 There were statistically significant differences between the two groups of infants with gestational age, birth weight, length of hospitalization, gestational age, and the proportion of newborns' weight <2000 g (P<0.05). The blood sampling volume and the incidence of anemia in preterm infants less than 32 weeks gestational age were significantly higher than those of 33 weeks gestational age preterm infants and 36 weeks gestational age premature infants, the difference was statistically significant (P<0.05). The incidence of NRDS, Apnea, CPAP, FI in the anemia group were higher than those in the non-anemia group, and the difference was statistically significant(P<0.05).Multiple factor Logistic regression analysis revealed that anemia of prematurity was associated with blood loss from laboratory testing and the basal hemoglobin level. The lower basal HB level and the greater blood sampling volume were risk factors for anemia in preterm infants (P<0.05).【Conclusion】 Anemia of prematurity is associated with the gestation, birth weight,the basal hemoglobin level and the blood loss due to laboratory testing. We should pay attention to the basal hemoglobin level, and decrease the blood loss from laboratory blood collection.
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Received: 19 March 2020
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2020, Vol. 37 
