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| Effect of Serum Uric Acid Level on the Risk of Diabetic Nephropathy in Patients with Diabetic Retinopathy |
| HU Shu-yang, XU Yan, ZHAO Heng-xia |
| The 904th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Wuxi, Jiangsu 214044 |
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Abstract 【Objective】 To investigate the effect of serum uric acid level on the risk of diabetic nephropathy (DN) in patients with type 2 diabetic retinopathy (DR). 【Methods】 A total of 100 patients with type 2 diabetes mellitus without diabetic retinopathy in our hospital were enrolled in the study. Serum uric acid level was measured. The patients were followed up for incidence of DR and DN. The correlation between serum uric acid and DN was evaluated and the influencing factors of DN in patients with type 2 diabetes DR were analyzed. 【Results】 The average follow-up time was (33.2±3.1) months. No patients were lost to follow-up. A total of 23 cases (23.0%) of DN occurred, and the no-DN rate was 87.0% (87/100) in 2 years. The uric acid level in patients with DN was higher than that in patients without DN (P<0.05). Kaplan-Meier and Log-rank test showed that patients with elevated blood uric acid levels had shorter DN accumulation time than patients with reduced serum uric acid levels (P<0.05). Cox analysis showed that age, duration of diabetes, carotid atherosclerotic plaque, fundus lesions, fasting blood glucose, and uric acid were independent factors affecting DN in patients with type 2 diabetes (P<0.05). ROC analysis showed that the area under the curve uric acid to predict DN in DR patients with type 2 diabetes was 0.74, the sensitivity was 65.2% and the specificity was 78.9%.【Conclusion】 The risk of DN is significantly increased in type 2 diabetic DR patients with elevated serum uric acid level, and serum uric acid is an effective biomarker for predicting DN in patients with type 2 diabetes.
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Received: 04 September 2019
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[1] Lee WJ, Sobrin L, Lee MJ, et al. The relationship between diabetic retinopathy and diabetic nephropathy in a population-based study in Korea (KNHANES V-2, 3)[J].Invest Ophthalmol Vis Sci,2014,55(10):6547-6553.
[2] Ahmed MH, Elwali ES, Awadalla H, et al. The relationship between diabetic retinopathy and nephropathy in Sudanese adult with diabetes: population based study[J].Diabetes Metab Syndr,2017,11 Suppl 1:S333-S336.
[3] Razi F, Nasli-Esfahani E, Bandarian F. Association of serum uric acid with nephropathy in Iranian type 2 diabetic patients[J].J Diabetes Metab Disord,2018,17(1):71-75.
[4] De Cosmo S, Viazzi F, Pacilli A, et al. Serum Uric Acid and Risk of CKD in Type 2 Diabetes[J].Clin J Am Soc Nephrol,2015,10(11):1921-1929.
[5] 中华医学会内分泌学分会.中国成人糖尿病肾脏病临床诊断的专家共识[J].糖尿病临床,2016,10(6):243-253.
[6] 郭毅飞,李雪锋,曾玉琴, 等.糖尿病患者血清瘦素、脂联素水平与糖尿病视网膜病变不同分期的相关性研究[J].临床和实验医学杂志,2019,18(1):43-46.
[7] Zhang J, Wang Y, Li L, et al. Diabetic retinopathy may predict the renal outcomes of patients with diabetic nephropathy[J].Ren Fail,2018,40(1):243-251.
[8] Lytvyn Y, Perkins BA, Cherney DZ. Uric acid as a biomarker and a therapeutic target in diabetes[J].Can J Diabetes,2015,39(3):239-246.
[9] 浦丹凤,王霞娟,马坚, 等.糖尿病视网膜病变合并糖尿病肾病的危险因素及其预测价值[J].中华老年多器官疾病杂志,2019,18(1):30-35.
[10] Bjornstad P,Lanaspa MA,Ishimoto T,et al.Fructose and uric acid in diabetic nephropathy[J].Diabetologia,2015,58(9):1993-2002.
[11] Kim SM,Lee SH,Kim YG,et al.Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy[J].Am J Physiol Renal Physiol,2015,308(9):F993-F1003. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1256-1258. |
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2020, Vol. 37 
