盐酸多奈哌齐联合尼麦角林治疗阿尔茨海默病临床疗效观察

doi:10.3969/j.issn.1671-7171.2020.05.015

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】 To investigate the effect of donepezil hydrochloride combined with nicergoline on the efficacy and stress status of elderly patients with Alzheimer's disease. 【Methods】 A retrospective analysis was made of 115 elderly patients with AD who were treated in our hospital from June 2015 to January 2018. According to the treatment methods, they were divided into observation group (n=65) and control group (n=50). The control group was treated with nimodipine, and the observation group was treated with donepezil on the basis of the control group. After treatment for one month, the therapeutic effect and the levels of serum homocysteine (Hcy), neuron specific enolase (NSE), central neuron specific protein (S100 β), orgotein (SOD), glutathione peroxidase (GSH Px), malondialdehyde (MDA), the end product of lipoxygenation, and the incidence of adverse reactions were compared. 【Results】 The total effective rate of the observation group was 92.31%, which was significantly higher than that of the control group (78.00%) (P<0.05). Before treatment, there was no significant difference in serum Hcy, NSE and S100βlevels between the two groups (P>0.05); after treatment, the serum Hcy, NSE, S100 β and MDA levels of the two groups decreased (P<0.05), SOD and GSH Px levels increased, SOD and GSH PX levels of the observation group were significantly higher than those of the control group (P< 0.05), and the changes of the observation group were more obvious. The total incidence of adverse reactions in the observation group was 6.15%, which was significantly lower than that in the control group (22.00%) (P<0.05).【Conclusion】 Donepezil hydrochloride combined with nimodipine in the treatment of elderly patients with AD has a significant effect, can significantly reduce the level of Hcy, NSE, S100β, regulate the level of SOD, GSH Px and MDA, and has a high safety, which is worthy of clinical application.

Key words： ALzheimerDisease Cholinesterase Inhibitors/TU

Received: 20 May 2019

PACS:

R742

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	GONG Ping
	ZHANG Wei
	SUN Yi-nan
	et al

Cite this article:

GONG Ping,ZHANG Wei,SUN Yi-nan, et al. Clinical Efficacy of Donepezil Hydrochloride Combined with Nimodipine in the Treatment of Elderly Patients with Alzheimer's Disease[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(5): 686-688.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.05.015 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I5/686

[1] 亓爱芹,朱峻岭,吕立峰,等.补肾益智汤联合卡巴拉汀治疗阿尔兹海默症临床效果及对血清缓激肽水平的影响[J].中华中医药学刊,2018,36(5):1252-1255.
[2] 徐盼盼,杨宁,李淑龙.基于支持张量机算法和3D脑白质图像的阿尔兹海默症诊断[J].中山大学学报(自然科学版),2018,57(2):52-60.
[3] Whitwell JL, Kantarci K, Weigand SD, et al. Microbleeds in atypical presentations of Alzheimer's disease: a comparison to dementia of the Alzheimer's type[J].J Alzheimers Dis,2015, 45(4):1109.
[4] 牛焱,王彬,相洁,李聪改, 等.阿尔兹海默症fMRI信号复杂度分析[J].太原理工大学学报,2017,48(5):841-846.
[5] 陈晓春. 新近推出的阿尔茨海默病诊断标准的临床实用性[J].中华神经科杂志,2012,45(5): 289-291.
[6] 姚伟梅,王惠琴.盐酸多奈哌齐片联合巴茱合剂治疗老年性痴呆的临床研究[J].中国临床药理学杂志,2016,32(20):1863-1865.
[7] 邸杰,崔春霞,刘鈡.盐酸多奈哌齐治疗老年性痴呆患者效果及对神经生长因子和Aβ的调控[J].中国老年学杂志,2016,36(16):3968-3969.
[8] Edmonds EC, Delano-Wood L, Galasko DR, et al. Subtle cognitive decline and biomarker staging in preclinical Alzheimer's disease[J].J Alzheimers Dis,2015, 47(1):231-242.
[9] 陈科.盐酸多奈哌齐治疗阿尔茨海默病的临床研究[J].中国临床药理学杂志,2016,32(11):981-983.
[10] 刘雪辉,曹平,钟文, 等.天智颗粒联合盐酸多奈哌齐片对轻中度肝阳上亢证血管性痴呆的临床分析[J].中国实验方剂学杂志,2016,22(7):177-181.
[11] Savage MJ, Holder DJ, Wu G, et al. Soluble BACE-1 activity and sAβPPβ concentrations in Alzheimer's disease and age-matched healthy control cerebrospinal fluid from the Alzheimer's disease neuroimaging initiative-1 baseline cohort[J].J Alzheimers Dis,2015, 46(2):431-440.
[12] Nishioka C, Poh C, Sun SW. Diffusion tensor imaging reveals visual pathway damage in patients with mild cognitive impairment and Alzheimer's disease[J].J Alzheimers Dis, 2015, 45(1):511-521.
[13] 樊东琼,李锐,雷旭, 等.阿尔兹海默症及轻度认知障碍静息态大尺度脑网络功能连接的改变[J].心理科学进展,2016,24(2):217-227.
[14] 徐运.缺血性脑卒中和阿尔兹海默症的转化医学研究[J].医学研究生学报,2016,29(1):21-23.
[15] Wojsiat J, Prandelli C, Laskowska-Kaszub K, et al. Oxidative stress and aberrant cell cycle in Alzheimer's disease lymphocytes: diagnostic prospects[J].J Alzheimers Dis,2015, 46(2):329.
[16] 刘珏,冯莎,王奕.匹伐他汀对阿尔兹海默症作用机制的研究进展[J].中国医院药学杂志,2015,35(15):1434-1438.
[17] Wood PL, Medicherla S, Sheikh N, et al. Targeted lipidomics of fontal cortex and plasma diacylglycerols (dag) in mild cognitive impairment (mci) and Alzheimer's disease: validation of dag accumulation early in the pathophysiology of Alzheimer's disease[J].J Alzheimers Dis,2015, 48(2):537.
[18] 耿赤子,魏建朝.功能康复训练联合盐酸多奈哌齐口服对帕金森病患者认知功能及生活质量的影响[J].山东医药,2015,55(23):56-58.
[19] 王里.盐酸多奈哌齐联合用药方案延缓老年痴呆患者病情进展的作用[J].中国老年学杂志,2014,34(20):5849-5851.
[20] K m l inen A, Herukka SK, Hartikainen P, et al. Cerebrospinal fluid biomarkers for Alzheimer's disease in patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis with the C9ORF72 repeat expansion[J].Dement Geriatr Cogn Disord,2015, 39(5-6):287-293.
[21] 范丽伟.丙戊酸镁缓释片联合盐酸多奈哌齐胶囊改善老年性痴呆患者认知行为的疗效观察[J].中国老年学杂志,2014,34(2):516-517.