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| Effects of Single-Direction Thoracoscopic Lobectomy on Oxygen Free Radicals and Vascular Endothelial Growth Factor in Lung Cancer Patients |
| DENG Yong, SHI Jin, YANG Wen-gang, et al |
| Department of Thoracic Surgery, People's Hospital of Sheyang County ,Jiangsu Sheyang 224300 |
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Abstract 【Objective】 To explore the effects of single-direction thoracoscopic lobectomy on oxygen radicals and vascular endothelial growth factor in patients with lung cancer. 【Methods】 The clinical data of 136 patients with lung cancer treated in our hospital were retrospectively analyzed and divided into thoracoscopic group (underwent single-direction thoracoscopic lobectomy) and control group (underwent radical thoracotomy) according to the treatment methods. Operation time, blood loss, thoracic drainage and hospitalization time were compared between the two groups. Serum levels of SOD, MDA, GSH-px, VEGF, MMP-9 and CRP were compared between the two groups before and 24h after surgery. Postoperative complications were compared between the two groups. 【Results】 The operation time, bleeding volume, pleural drainage and hospitalization time of patients in the thoracoscopic group were lower than those in the control group (P<0.05); the serum SOD and GSH-px levels of patients in the thoracoscopic group were significantly higher than those in the control group (P<0.05), and the MDA,VEGF,MMP-9 and CRP levels were lower than those in the control group (P<0.05).【Conclusion】 Single-direction thoracoscopic lobectomy is effective in the treatment of lung cancer. the trauma to patients is small, which can reduce the oxidative stress response of patients and reduce the expression of VEGF, and the incidence of complications is low, which is worthy of clinical application.
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Received: 18 July 2019
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[1] 俞巍.胸腔镜手术治疗老年早期肺癌的效果及对术后氧化应激的影响分析[J].中南医学科学杂志,2018,46(5):535-537.
[2] 杨泽波.胸腔镜肺癌手术对老年非小细胞肺癌患者心肺功能及血清免疫指标的影响[J].中国老年学杂志,2018,38(1):137-139.
[3] 张振龙,潘小杰,郭天兴,等.单操作孔全胸腔镜肺癌根治术124例[J].中国微创外科杂志,2017,17(9):844-846.
[4] 刘伦旭,车国卫,蒲强,等.单向式全胸腔镜肺叶切除术[J].中华胸心血管外科杂志,2008,24(3):156-158.
[5] 刘成武,郭成林,林锋,等.单向式胸腔镜肺叶或肺段切除术治疗Ⅰ期肺癌的远期疗效[J].中华外科杂志,2015,53(10):742-746.
[6] 支修益,石远凯,于金明.中国原发性肺癌诊疗规范(2015年版)[J].中华肿瘤杂志,2015,37(1):67-78.
[7] 喻本桐,黄云鹤.探讨非小细胞肺癌的手术治疗[J].中国医师杂志,2015,17(11):1601-1604.
[8] 李栋,郑江敏,李占新,等.ⅢA期肺癌胸腔镜辅助小切口治疗后的疗效及生存分析[J].医学综述,2015,21(17):3256-3259.
[9] 袁世立,赵昌学,周斌.术前新辅助化疗对非小细胞肺癌围手术期相关指标及疗效的影响[J].中国医师杂志,2018,20(3):430-432.
[10] 张舸,薛雷,赵晓龙.单向式全胸腔镜肺叶切除术治疗早期非小细胞肺癌[J].中日友好医院学报,2015,29(4):217-220.
[11] 强小鹏,孙健勇,朱喜明,等.单向式胸腔镜肺叶、全肺切除及淋巴结清扫手术体会[J].肿瘤学杂志,2016,22(6):521-522.
[12] 苏玉强,郑仲磊.不同麻醉方法对肺癌根治术患者应激反应及免疫功能的影响[J].中国肿瘤临床与康复,2017,24(7):824-827.
[13] 曹洋,刘涛,王鹏飞.单孔与三孔胸腔镜手术治疗肺癌的机体疼痛程度、创伤程度比较[J].海南医学院学报,2017,23(8):1095-1098.
[14] Reichert M,Kerber S,Amati AL,et al.Total video-assisted thoracoscopic(VATS) resection of a left-sided sulcus superior tumor after induction radiochemotherapy: video and review[J].Surg Endosc,2015,29(8):2407-2409.
[15] 孔海霞,李洪娟,徐婧玥,等.肺癌患者血清MMP-9、HE4、CYFRA21-1、CEA、NSE水平变化及其临床意义[J].山东医药,2017,57(32):73-75. |
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2020, Vol. 37 
