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| Serum Levels and Significance of NSE, IL-26 and T lymphocyte Subsets in Patients with Acute Herpes Zoster |
| ZHAO Yan-xia, WANG Shang-shang, WANG Lin, et al |
| Rugao People's Hospital, Jiangsu Rugao 226500 |
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Abstract 【Objective】 To investigate the levels and significance of serum neuron specific enolase (NSE), interleukin-26 (IL-26) and T lymphocyte subsets in patients with acute herpes zoster. 【Methods】 Seventy-five patients with acute herpes zoster treated in our hospital from February 2016 to February 2019 were selected as the observation group, and 80 healthy volunteers were selected as the control group. Serum NSE, IL-26 and T lymphocyte subsets were measured in the two groups. 【Results】 The levels of serum NSE and IL-26 in the observation group were (13.10±2.71) g/L and (14.40±2.11) pg/mL, respectively, which were significantly higher than those in the control group (P<0.05), while the levels of CD3+, CD4+, and CD8+ were (56.69±10.01)%, (29.82±7.13)% and (25.52±6.82)%, respectively, which were significantly lower than those in the control group (P<0.05). Serum NSE and IL-26 in patients with moderate and severe pain were (14.91±2.00) g/L and (16.72 ±2.43) pg/mL, which were significantly higher than those in patients with mild pain (P<0.05). There were no significant differences in serum levels of CD3+, CD4+ and CD8+ among patients with mild, moderate and severe pain (P>0.05). Serum NSE and IL-26 were positively correlated with VAS score (r=0.401 and 0.332, respectively, P<0.05), while serum levels of CD3+, CD4+ and CD8+ were not correlated with VAS score (P>0.05). 【Conclusion】 The levels of serum NSE and IL-26 are increased and T lymphocyte subsets are disordered in patients with herpes zoster in acute stage, among which NSE and IL-26 are related to the degree of pain.
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Received: 10 July 2019
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[1] 马天明, 韩宪伟. 带状疱疹患者血清神经元特异性烯醇化酶水平的变化及意义[J].实用临床医药杂志, 2017, 21(13):100-102.
[2] 张馨月, 钟婷婷, 钟建桥,等. 带状疱疹患者疱液及外周血病毒载量与血浆S100β和神经元特异性烯醇化酶水平的研究[J].中华皮肤科杂志, 2017, 50(2):109-112.
[3] 徐小静, 武文艳, 张二清,等. GFAP、APN、血液指标与缺血缺氧性脑病新生儿脑损伤程度的关系[J].医学临床研究, 2018, 35(10):1956-1958.
[4] 王璐, 任长和, 赵姣妹,等. 带状疱疹病人T淋巴细胞亚群凋亡与CD95表达的关系[J].中国疼痛医学杂志, 2018, 24(5):29-35.
[5] 冯金鸽, 周舒, 朱芸, 等.皮肤性病学临床教学模式研究[J].中国医药导报, 2014, 11(4):119-121.
[6] 辛蔚妮, 曾博, 许青峰, 等. 视觉模拟评分法评估根管治疗术后疼痛程度及疼痛相关因素分析[J].中华口腔医学研究杂志, 2019, 13(5):278-283.
[7] 高岩, 姚杰, 付晓华. 活血散瘀汤合阿昔洛韦治疗带状疱疹后遗神经痛疗效观察[J].现代中西医结合杂志, 2018,18(15):1658-1661.
[8] 皮治兵, 张钧凯, 彭宇, 等. 超声引导脊神经后支脉冲射频治疗老年患者下腰部带状疱疹性神经痛的疗效分析[J].中华医学杂志, 2018, 98(1):733-737.
[9] 吴英桂, 欧伟洪, 陈丽洁. 红光照射疗法治疗带状疱疹后遗神经痛的效果及对患者生活质量的影响[J].天津医药, 2018, 46(3):288-291.
[10] 蔡玲琴, 朱希聪, 张灵鹏, 等.急性期带状疱疹患者的临床特征与T细胞亚群的关系[J].中华全科医学, 2017, 15(1):39-41. |
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2020, Vol. 37 
