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| Effects of Danhong Injection on Coagulation and Fibrinolysis Function, Platelet Activation, Inflammatory Factors and Oxidative Stress after Emergency PCI |
| HU Zi-wei |
| Wuhan Central Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology, Hubei Wuhan, 430000 |
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Abstract 【Objective】 To investigate the effects of Danhong injection on coagulation and fibrinolysis function, platelet activation, inflammatory factors and oxidative stress after emergency percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). 【Methods】A total of 86 patients with AMI who underwent emergency PCI treatment in our hospital were randomly divided into two groups: the observation group and the control group. The patients in the two groups were continuously treated for 14 days with conventional western medicine, while patients in the observation group received Danhong injection. The coagulation and fibrinolytic function: thrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and D-dimer (DD), platelet activation function: Lysosomal membrane glycoprotein (CD63), platelet alpha granule surface membrane glycoprotein (CD62p), monocyte platelet aggregates (MPA), inflammatory factor indicators: C-reactive protein (CRP), interleukin-6 (IL-6) ) and oxidative stress indicators: peroxidase dismutase (SOD) and malondialdehyde (MDA) were observed before PCI and 14 days after PCI and compared between the two groups. 【Results】 ①The total effective rate of the observation group was higher than that of the control group (90.70% vs 72.09%, respectively, P<0.05).②There was no significant difference in coagulation and fibrinolysis function between the two groups before treatment (P>0.05).After treatment, the coagulation and fibrinolysis function (APTT,PT,FIB and D-Dimer) of the two groups was improved obviously; and the improvement degree of the observation group was better than that of the control group (P<0.05).③After treatment, the platelet activation function (CD63,CD62p and MPA) in the two groups was significantly lower than that before treatment; and the decrease in the observation group was more significant than that in the control group (P<0.05).④After treatment, the levels of inflammatory factors (CRP and IL-6) in the two groups were both lower than before; and the decrease in the observation group was more significant than that in the control group at the same time (P<0.05).⑤After treatment, the index of oxidative stress (SOD and MDA) in the two groups was obviously improved; and the degree of improvement in the observation group was better than that in the control group (P<0.05). 【Conclusion】Application of routine western medicine combined with Danhong injection after emergency PCI can significantly improve clinical efficacy, reduce blood viscosity, improve hemodynamics, inhibit immune inflammatory and oxidative stress response, and thus stabilize atherosclerotic plaques and improve the prognosis.
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Received: 19 March 2019
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2020, Vol. 37 
