Abstract【Objective】To explore the clinical value of ropacaine nerve block in neurosurgery craniotomy.【Methods】A total of 98 patients who underwent carniotomy from October 2016 to December 2017 were randomly divided into group A and group B, with 49 cases in each group. Group A received ropacaine nerve block combined with intravenous general anesthesia, while group B only received intravenous general anesthesia. The heart rate (HR), mean arterial pressure (MAP), bispectral index (BIS) at different time points were recorded; postoperative pain (VAS) score, adverse reactions, serum substance P and serotonin (5-HT) before and after surgery were compared in the two groups. 【Results】At the time of T0~T3, there were no significant differences in values of HR, MAP and BIS between group A and the group B (P>0.05). The VAS scores at 4 h, 12 h, and 24 h after surgery in the observation group were significantly lower than those in the control group; and the difference were statistically significant (P<0.05). At 24 hours after operation, serum levels of substance P and 5-HT in group A were significantly lower than those in group B (P<0.05), though there were no significant difference before surgery. The incidence of adverse reactions in patients of group A was 6.12% (3/49) and that of group B was 12.24% (6/49), which did not show statistically significant (χ2=1.101,P=0.294>0.05).【Conclusion】 The use of ropacaine nerve block in neurosurgery craniotomy is beneficial to reduce postoperative pain and decrease serum substance P and 5-HT levels.
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2020, Vol. 37 
