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| Changes of sICAM-1, P- selectin and D-dimer Associating with the Severity of Acute Pancreatitis |
| ZHANG Ling, HUANG Yin, YANG Ting-ting |
| Jiangsu Yixing People's Hospital Inspection Division 214200 |
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Abstract 【Objective】To investigate the changes of serum sICAM-1, P-selectin and D-dimer(D-D) levels in patients with acute pancreatitis and their relationship with the severity of the disease. 【Methods】Patients with mild pancreatitis (MAP,n=36) and severe pancreatitis (SAP,n=44) plus 25 healthy people (control group) were selected for the study. On day 1 (d1) and day 7 (d7) of hospital admission, venous blood was collected to detect sICAM-1, P-selectin and D-D . The changes and correlations of each index in the three groups were analyzed. 【Results】On the first day of admission, the levels of sICAM-1, P-selectin and D-D in all subjects were SAP group >MAP group>control group (P<0.05). On d7, the levels of sICAM-1 and P-selectin in the MAP group and SAP group were significantly lower than those on d1 (P<0.05), while the D-D level was higher than that of d1 (P<0.05).Furthermore, the levels of P-selectin and sICAM-1 in the MAP group were significantly lower than those in the SAP group (P<0.05), while the level of D-D were the opposite (P<0.05). Pearson or Spearman correlation analysis showed that sICAM was positively correlated with P-selectin and D-D (P<0.01) and P-selectin was positively correlated with D-D (P<0.01) on d1 and d7. 【Conclusion】The changes of sICAM-1, P-selectin and D-D are closely related to the occurrence and development of acute pancreatitis, which can be used as biological indicators for evaluating the condition of patients with acute pancreatitis.
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Received: 30 August 2018
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2019, Vol. 36 
