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| Changes of Serum Levels of IL-6, S100β , IL-1β and IL-2 in Patients with Schizophrenia |
| HUANG Xing-dong, ZHOU Jun, CHEN Yun-long,et al |
| Three Gorges Minkang Hospital of Chongqing,Chongqing 404300 |
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Abstract 【Objective】To explore the changes and significance of serum interleukin-6 (IL-6), calcium binding protein β (S100β), interleukin-1β (IL-1β) and interleukin-2 (IL-2) in patients with first-episode schizophrenia. 【Methods】Ninety patients with first-episode schizophrenia admitted to our hospital from March 2015 to May 2018 were divided into positive symptoms group (n=48) and negative symptoms group (n=42) according to their symptoms. Sixty healthy volunteers in the same period were selected as the control group. The serum levels of IL-6, S100β, IL-1β and IL-2 were compared among the three groups, and the relationship between serum levels of IL-6, S100beta, IL-1β and IL-2 and PANSS score was analyzed. 【Results】The serum levels of IL-6, S100β and IL-1β in the positive and negative symptoms groups were significantly higher than those in the control group, and the serum levels of IL-2 were significantly lower than those in the control group (P<0.05); the serum levels of IL-6 in the positive symptoms group and the negative symptoms group were significantly higher than those in the control group (P<0.05). The scores of positive symptoms, negative symptoms and PANSS in the positive symptoms group and negative symptoms group were significantly higher than those in the control group, and the scores of positive symptoms in the positive symptoms group were significantly higher than those in the negative symptoms group (P<0.05). There was a significant positive correlation between serum IL-1beta and PANSS total score (P<0.05). There was no significant correlation between serum IL-6, S100β and IL-2 levels and PANSS total score (P>0.05).【Conclusion】The serum levels of IL-6, S100β and IL-1β in schizophrenia patients increased significantly, while the expression of IL-2 decreased significantly. The expression of IL-1beta is closely related to the PANSS score of schizophrenia patients.
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Received: 26 September 2018
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2019, Vol. 36 
