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| Effect of General Anesthesia Combined with Thoracic Paravertebral Nerve Block on Postoperative Recovery, Inflammatory Response and Cognitive Function in Patients with Lung Cancer |
| XU Zong-xue, HE Cui-ping, CHENG Min,et al |
| Department of Anesthesiology, General Hospital of Huainan Oriental Hospital Group, Huainan, Anhui 232001, China |
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Abstract 【Objective】 To investigate the effects of general anesthesia combined with thoracic paravertebral nerve block (TPVB) on postoperative recovery, inflammatory response and cognitive function in patients undergoing radical thoracoscopic lung cancer mastectomy. 【Methods】A total of 80 patients with NSCLC who underwent thoracoscopic radical resection of lung cancer in our hospital from April 2014 to April 2019 were randomly assigned to the observation group and the control group according to the patient's admission time. The observation group received general anesthesia combined with TPVB while the control group underwent general anesthesia. The operation time, single lung ventilation time, surgical bleeding volume, recovery time, extubation time, propofol dosage, remifentanil dosage, serum interleukin-6 (IL-6),interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), cortisol (Cor), adiponectin (ADP), S100 protein, and cognitive dysfunction (PCOD) were compared between the two groups. 【Results】There were no significant differences in the operation time, single lung ventilation time and surgical bleeding volume between the observation group and the control group (P>0.05). The recovery time of the observation group was longer than that of the control group (P<0.05). The extubation time, the dosage of propofol and remifentanil of the observation group were significantly lower than those of the control group (P<0.05). There were no significant differences in serum levels of IL-6, IL-10, TNF-α, Cor, ADp and S100 protein between the two groups before surgery (P>0.05). At 24 hours after operation, the serum levels of IL-6, IL-10, TNF-α, Cor and S100 protein in the observation group were lower than those in the control group (P<0.05). While the ADP level the observation group was higher than in the control group (P<0.05) at 24 hoours after surgery, PCOD incidence rate in the observation group was 10.00%, which was lower than that in the control group (31.11% ),and the difference was statistically significant (P<0.05).【Conclusion】General anesthesia combined with TPVB can prolong the recovery time, reduce the time of extubation and the amount of anesthetic drugs, reduce the inflammatory response and the incidence of PCOD in patients undergoing thoracoscopic radical resection of lung cancer.
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Received: 06 May 2019
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2019, Vol. 36 
